DegronMD

Uniprot ID: O43395

Source protein: U4/U6 small nuclear ribonucleoprotein Prp3

Source gene: PRPF3

Class: DEG_ODPH_VHL_1

Location: 317:329

E3 ligase: VHL

DEGRON score: 0.6078

ASA_SCORE: 96.1692

COIL: 0.7255

CONS_SCORE: 0.4531

DSS_SCORE: 0.539

HELIX: 0.1323

FCONS_SCORE: 0.9208

RIG_SCORE: 0.718

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D312E	TCGA-10-0935	OV	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.1944
p.I338T	TCGA-A5-A0G2	UCEC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.0833
p.K334N	TCGA-AP-A056	UCEC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.3056
p.F310L	TCGA-AP-A1DV	UCEC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.1389
p.A339T	TCGA-AX-A1CE	UCEC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.0556
p.A339T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.0556
p.A339T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.0556
p.S316F	TCGA-AZ-4315	COAD	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.3056
p.D312G	TCGA-BR-4257	STAD	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.1944
p.R324I	TCGA-EO-A22R	UCEC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.6991
p.E336Q	TCGA-T2-A6WX	HNSC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.1389
p.E336Q	TCGA-VS-A8QA	CESC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.1389
p.E336Q	ACH-000694	Esophageal Cancer	CCLE	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.1389
p.P336S	DO49795	BLCA	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.1389
p.S318L	DO222762	COCA	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.7667
p.S318L	DO46566	OV	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.7667
p.S318L	DO43154	UCEC	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.7667
p.T313R	DO20171	KIRC	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.2222
p.R311Q	DO228949	LICA	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.1667
p.R311Q	DO50288	SKCM	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.1667
p.R311L	DO229015	LICA	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.1667
p.I335T	DO228346	MALY	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.1667
p.P326S	DO219481	SKCM	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.6752
p.A322V	DO41361	UCEC	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.6936
p.I338V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.0833
p.I338V	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.0833
p.R322H	SIDM01619	Endometrial Carcinoma	GDSC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.7133
p.R322H	ACH-000984	Endometrial/Uterine Cancer	CCLE	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.7133
p.D331N	ACH-000694	Esophageal Cancer	CCLE	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPSQRQRRTFKF

Degron related mutations and impact score

Drug responses associated with PRPF3 mutations

All proteins holding degron of IAPSQRQRRTFKF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43395	U4/U6 small nuclear ribonucleoprotein Prp3	DEG_ODPH_VHL_1	317:329	IAPSQRQRRTFKF	VHL	0.6078	More...