DegronMD - O43395(PRPF3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D312E	TCGA-10-0935	OV	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.1944
p.I338T	TCGA-A5-A0G2	UCEC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.0833
p.R180Q	TCGA-A5-A2K3	UCEC	TCGA	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.2222
p.K334N	TCGA-AP-A056	UCEC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation substituting flanking lysine	0.3056
p.F310L	TCGA-AP-A1DV	UCEC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.1389
p.A339T	TCGA-AX-A1CE	UCEC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.0556
p.A339T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.0556
p.A339T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.0556
p.S316F	TCGA-AZ-4315	COAD	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.3056
p.L160M	TCGA-BR-4184	STAD	TCGA	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.0556
p.D312G	TCGA-BR-4257	STAD	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.1944
p.P165H	TCGA-D3-A2JK	SKCM	TCGA	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.1944
p.P173S	TCGA-D9-A1JW	SKCM	TCGA	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation altering degron motif	0.6752
p.P173L	TCGA-D9-A1JW	SKCM	TCGA	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation altering degron motif	0.7582
p.E179K	TCGA-DK-A6B2	BLCA	TCGA	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.25
p.R324I	TCGA-EO-A22R	UCEC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation altering degron motif	0.6991
p.E336Q	TCGA-T2-A6WX	HNSC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.1389
p.E336Q	TCGA-VS-A8QA	CESC	TCGA	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.1389
p.E336Q	ACH-000694	Esophageal Cancer	CCLE	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.1389
p.K171N	TCGA-TN-A7HL	HNSC	TCGA	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation altering degron motif	0.5806
p.P336S	DO49795	BLCA	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.1389
p.G173A	DO4713	BRCA	ICGC	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation altering degron motif	0.754
p.S318L	DO222762	COCA	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation altering degron motif	0.7667
p.S318L	DO46566	OV	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation altering degron motif	0.7667
p.S318L	DO43154	UCEC	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation altering degron motif	0.7667
p.T313R	DO20171	KIRC	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.2222
p.R311Q	DO228949	LICA	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.1667
p.R311Q	DO50288	SKCM	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.1667
p.R311L	DO229015	LICA	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.1667
p.I335T	DO228346	MALY	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.1667
p.P326S	DO219481	SKCM	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation altering degron motif	0.6752
p.R163Q	DO38711	STAD	ICGC	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.1389
p.R163Q	DO42049	UCEC	ICGC	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.1389
p.R163Q	DO41903	UCEC	ICGC	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.1389
p.A322V	DO41361	UCEC	ICGC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation altering degron motif	0.6936
p.P170T	SIDM00216	Colorectal Carcinoma	GDSC	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation altering degron motif	0.7031
p.P170T	SNU-175	large intestine	COSMIC	PKTPSSS	DEG_SCF_FBW7_1	170:176	Mutation altering degron motif	0.7031
p.I338V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.0833
p.I338V	CML-T1	haematopoietic and lymphoid tissue	COSMIC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.0833
p.R322H	SIDM01619	Endometrial Carcinoma	GDSC	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation altering degron motif	0.7133
p.R322H	ACH-000984	Endometrial/Uterine Cancer	CCLE	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation altering degron motif	0.7133
p.D331N	ACH-000694	Esophageal Cancer	CCLE	IAPSQRQRRTFKF	DEG_ODPH_VHL_1	317:329	Mutation rewiring degron network	0.2778

Kaplan plot for PRPF3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRPF3

UniProt ID: O43395

Entrez ID: 9129

Protein name: U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRPF3 in