DegronMD

Uniprot ID: O43395

Source protein: U4/U6 small nuclear ribonucleoprotein Prp3

Source gene: PRPF3

Class: DEG_SCF_FBW7_1

Location: 170:176

E3 ligase: FBXW7

DEGRON score: 0.9702

ASA_SCORE: 92.9286

COIL: 0.9493

CONS_SCORE: 0.371

DSS_SCORE: 0.8471

HELIX: 0.0226

FCONS_SCORE: 1.0414

RIG_SCORE: 0.5363

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R180Q	TCGA-A5-A2K3	UCEC	TCGA	PKTPSSS	DEG_SCF_FBW7_1	0.2222
p.L160M	TCGA-BR-4184	STAD	TCGA	PKTPSSS	DEG_SCF_FBW7_1	0.0556
p.P165H	TCGA-D3-A2JK	SKCM	TCGA	PKTPSSS	DEG_SCF_FBW7_1	0.1944
p.P173S	TCGA-D9-A1JW	SKCM	TCGA	PKTPSSS	DEG_SCF_FBW7_1	0.6752
p.P173L	TCGA-D9-A1JW	SKCM	TCGA	PKTPSSS	DEG_SCF_FBW7_1	0.7582
p.E179K	TCGA-DK-A6B2	BLCA	TCGA	PKTPSSS	DEG_SCF_FBW7_1	0.25
p.K171N	TCGA-TN-A7HL	HNSC	TCGA	PKTPSSS	DEG_SCF_FBW7_1	0.5806
p.G173A	DO4713	BRCA	ICGC	PKTPSSS	DEG_SCF_FBW7_1	0.754
p.R163Q	DO38711	STAD	ICGC	PKTPSSS	DEG_SCF_FBW7_1	0.1389
p.R163Q	DO42049	UCEC	ICGC	PKTPSSS	DEG_SCF_FBW7_1	0.1389
p.R163Q	DO41903	UCEC	ICGC	PKTPSSS	DEG_SCF_FBW7_1	0.1389
p.P170T	SIDM00216	Colorectal Carcinoma	GDSC	PKTPSSS	DEG_SCF_FBW7_1	0.7031
p.P170T	SNU-175	large_intestine	COSMIC	PKTPSSS	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43395	U4/U6 small nuclear ribonucleoprotein Prp3	DEG_SCF_FBW7_1	170:176	PKTPSSS	FBXW7	0.9702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons