DegronMD

Uniprot ID: P08F94

Source protein: Fibrocystin

Source gene: PKHD1

Class: DEG_ODPH_VHL_1

Location: 461:473

E3 ligase: VHL

DEGRON score: 0.6104

ASA_SCORE: 40.1154

COIL: 0.3389

CONS_SCORE: 0.4652

DSS_SCORE: 0.242

HELIX: 0.0099

FCONS_SCORE: 1.2635

RIG_SCORE: 0.7459

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G466W	TCGA-86-A456	LUAD	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.6714
p.G466W	DO24890	LUAD	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.6714
p.A462T	TCGA-95-7562	LUAD	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.7139
p.A462T	DO51196	LUAD	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.7139
p.P480T	TCGA-CN-6019	HNSC	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.1389
p.P480T	DO14316	HNSC	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.1389
p.V482A	TCGA-DF-A2KU	UCEC	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.0833
p.V482A	DO223286	UCEC	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.0833
p.H459Y	TCGA-EB-A6R0	SKCM	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.2778
p.H459Y	TCGA-EE-A2GM	SKCM	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.2778
p.H459Y	DO37555	SKCM	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.2778
p.H459Y	DO48646	SKCM	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.2778
p.Y452N	TCGA-LG-A6GG	LIHC	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.5278
p.Y452N	DO49699	LIHC	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.5278
p.L478M	TCGA-QQ-A5VC	SARC	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.1944
p.L478M	DO220250	SARC	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.1944
p.Y453C	DO228190	LICA	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.1111
p.Y452C	DO231934	LICA	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.5278
p.A462D	DO229018	LICA	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.7793
p.H474Y	DO222638	MELA	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.3056
p.E457D	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.2222
p.E457D	KYSE-450	oesophagus	COSMIC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08F94	Fibrocystin	DEG_ODPH_VHL_1	461:473	IAPSRGMRIGVQI	VHL	0.6104	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons