DegronMD - P08F94(PKHD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G340V	TCGA-34-8454	LUSC	TCGA	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.1944
p.G340V	DO50094	LUSC	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.1944
p.G466W	TCGA-86-A456	LUAD	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation altering degron motif	0.6714
p.G466W	DO24890	LUAD	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation altering degron motif	0.6714
p.A462T	TCGA-95-7562	LUAD	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation altering degron motif	0.7139
p.A462T	DO51196	LUAD	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation altering degron motif	0.7139
p.V338I	TCGA-AA-3947	COAD	TCGA	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.25
p.V338I	DO8192	COAD	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.25
p.D317Y	TCGA-AG-A002	READ	TCGA	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.0556
p.R328L	TCGA-AX-A2HC	UCEC	TCGA	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.8428
p.R328L	DO41572	UCEC	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.8428
p.P480T	TCGA-CN-6019	HNSC	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.1389
p.P480T	DO14316	HNSC	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.1389
p.V482A	TCGA-DF-A2KU	UCEC	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.0833
p.V482A	DO223286	UCEC	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.0833
p.H459Y	TCGA-EB-A6R0	SKCM	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.2778
p.H459Y	TCGA-EE-A2GM	SKCM	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.2778
p.H459Y	DO37555	SKCM	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.2778
p.H459Y	DO48646	SKCM	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.2778
p.R328Q	TCGA-FI-A2D5	UCEC	TCGA	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.7329
p.R328Q	DO222884	COCA	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.7329
p.R328Q	DO50680	ORCA	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.7329
p.R328Q	DO41331	UCEC	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation altering degron motif	0.7329
p.Y452N	TCGA-LG-A6GG	LIHC	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation blocking phosphorylation signal	0.5278
p.Y452N	DO49699	LIHC	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation blocking phosphorylation signal	0.5278
p.L478M	TCGA-QQ-A5VC	SARC	TCGA	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.1944
p.L478M	DO220250	SARC	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.1944
p.Y453C	DO228190	LICA	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.1111
p.Y452C	DO231934	LICA	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation blocking phosphorylation signal	0.5278
p.L341M	DO228952	LICA	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.1667
p.A462D	DO229018	LICA	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation altering degron motif	0.7793
p.L343M	DO229032	LICA	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.1111
p.T321N	DO229006	LICA	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.1667
p.H474Y	DO222638	MELA	ICGC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.3056
p.E339D	DO46493	OV	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.2222
p.D336N	SIDM00190	Melanoma	GDSC	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.3056
p.D336N	CP66-MEL	skin	COSMIC	NRGLLFEVG	DEG_APCC_DBOX_1	327:335	Mutation rewiring degron network	0.3056
p.E457D	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.2222
p.E457D	KYSE-450	oesophagus	COSMIC	IAPSRGMRIGVQI	DEG_ODPH_VHL_1	461:473	Mutation rewiring degron network	0.2222

Kaplan plot for PKHD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKHD1

UniProt ID: P08F94

Entrez ID: 5314

Protein name: Fibrocystin (Polycystic kidney and hepatic disease 1 protein) (Polyductin) (Tigmin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKHD1 in