DegronMD

Uniprot ID: P08F94

Source protein: Fibrocystin

Source gene: PKHD1

Class: DEG_APCC_DBOX_1

Location: 327:335

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6427

ASA_SCORE: 34.0222

COIL: 0.4463

CONS_SCORE: 0.5064

DSS_SCORE: 0.4233

HELIX: 0.0341

FCONS_SCORE: 1.5389

RIG_SCORE: 0.7832

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G340V	TCGA-34-8454	LUSC	TCGA	NRGLLFEVG	DEG_APCC_DBOX_1	0.1944
p.G340V	DO50094	LUSC	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	0.1944
p.V338I	TCGA-AA-3947	COAD	TCGA	NRGLLFEVG	DEG_APCC_DBOX_1	0.25
p.V338I	DO8192	COAD	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	0.25
p.D317Y	TCGA-AG-A002	READ	TCGA	NRGLLFEVG	DEG_APCC_DBOX_1	0.0556
p.R328L	TCGA-AX-A2HC	UCEC	TCGA	NRGLLFEVG	DEG_APCC_DBOX_1	0.8428
p.R328L	DO41572	UCEC	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	0.8428
p.R328Q	TCGA-FI-A2D5	UCEC	TCGA	NRGLLFEVG	DEG_APCC_DBOX_1	0.7329
p.R328Q	DO222884	COCA	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	0.7329
p.R328Q	DO50680	ORCA	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	0.7329
p.R328Q	DO41331	UCEC	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	0.7329
p.L341M	DO228952	LICA	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	0.1667
p.L343M	DO229032	LICA	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	0.1111
p.T321N	DO229006	LICA	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	0.1667
p.E339D	DO46493	OV	ICGC	NRGLLFEVG	DEG_APCC_DBOX_1	0.2222
p.D336N	SIDM00190	Melanoma	GDSC	NRGLLFEVG	DEG_APCC_DBOX_1	0.3056
p.D336N	CP66-MEL	skin	COSMIC	NRGLLFEVG	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P08F94	Fibrocystin	DEG_APCC_DBOX_1	327:335	NRGLLFEVG	APC,CDC20,FZR1	0.6427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons