DegronMD

Uniprot ID: O75943

Source protein: Cell cycle checkpoint protein RAD17

Source gene: RAD17

Class: LIG_APCC_ABBA_1

Location: 193:198

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8515

ASA_SCORE: 49.0167

COIL: 0.0823

CONS_SCORE: 0.4083

DSS_SCORE: 0.0448

HELIX: 0.8923

FCONS_SCORE: 1.2827

RIG_SCORE: 0.9302

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M186L	TCGA-29-1707	OV	TCGA	IAVFKE	LIG_APCC_ABBA_1	0.1389
p.A203V	TCGA-2W-A8YY	CESC	TCGA	IAVFKE	LIG_APCC_ABBA_1	0.1944
p.Q190H	TCGA-AG-3896	READ	TCGA	IAVFKE	LIG_APCC_ABBA_1	0.25
p.L200I	TCGA-B5-A0JY	UCEC	TCGA	IAVFKE	LIG_APCC_ABBA_1	0.2778
p.I193T	TCGA-B5-A3FA	UCEC	TCGA	IAVFKE	LIG_APCC_ABBA_1	0.7078
p.H185N	TCGA-D9-A1JX	SKCM	TCGA	IAVFKE	LIG_APCC_ABBA_1	0.1111
p.G202R	DO51607	CESC	ICGC	IAVFKE	LIG_APCC_ABBA_1	0.2222
p.A192V	DO223732	CESC	ICGC	IAVFKE	LIG_APCC_ABBA_1	0.3056
p.R206I	DO9002	COAD	ICGC	IAVFKE	LIG_APCC_ABBA_1	0.1111
p.L189I	DO43041	UCEC	ICGC	IAVFKE	LIG_APCC_ABBA_1	0.2222
p.K194N	HCT-15	large_intestine	COSMIC	IAVFKE	LIG_APCC_ABBA_1	0.6918
p.I185L	WSU-DLCL2	haematopoietic_and_lymphoid_tissue	COSMIC	IAVFKE	LIG_APCC_ABBA_1	0.1111
p.E204Q	HDQ-P1	breast	COSMIC	IAVFKE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75943	Cell cycle checkpoint protein RAD17	LIG_APCC_ABBA_1	193:198	IAVFKE	APC,CDC20,FZR1	0.8515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons