DegronMD - O75943(RAD17)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M186L	TCGA-29-1707	OV	TCGA	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation rewiring degron network	0.1389
p.A203V	TCGA-2W-A8YY	CESC	TCGA	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation rewiring degron network	0.1944
p.E73Q	TCGA-AC-A23H	BRCA	TCGA	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.5633
p.Q190H	TCGA-AG-3896	READ	TCGA	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation rewiring degron network	0.25
p.P62S	TCGA-AX-A2HD	UCEC	TCGA	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.25
p.P62S	ACH-001570	Skin Cancer	CCLE	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.25
p.L200I	TCGA-B5-A0JY	UCEC	TCGA	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation rewiring degron network	0.2778
p.I193T	TCGA-B5-A3FA	UCEC	TCGA	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation altering degron motif	0.7078
p.S59N	TCGA-CK-4951	COAD	TCGA	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1667
p.E79Q	TCGA-CR-6481	HNSC	TCGA	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1667
p.H185N	TCGA-D9-A1JX	SKCM	TCGA	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation rewiring degron network	0.1111
p.N68H	TCGA-EO-A22U	UCEC	TCGA	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.6312
p.S81L	TCGA-F7-8489	HNSC	TCGA	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation blocking phosphorylation signal	0.5556
p.E78K	DO219024	BLCA	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1944
p.E62Q	DO2401	BRCA	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.25
p.E76K	DO219623	BRCA	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.25
p.G202R	DO51607	CESC	ICGC	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation rewiring degron network	0.2222
p.A192V	DO223732	CESC	ICGC	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation rewiring degron network	0.3056
p.R206I	DO9002	COAD	ICGC	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation rewiring degron network	0.1111
p.E68Q	DO14990	HNSC	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.6744
p.S70L	DO14319	HNSC	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.6556
p.P79S	DO45346	LUAD	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1667
p.L189I	DO43041	UCEC	ICGC	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation rewiring degron network	0.2222
p.N57H	DO43755	UCEC	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1111
p.K194N	HCT-15	large intestine	COSMIC	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation altering degron motif	0.6918
p.I185L	WSU-DLCL2	haematopoietic and lymphoid tissue	COSMIC	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation rewiring degron network	0.1111
p.R75Q	SKG-IIIa	cervix	COSMIC	KRGNLSSLE	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.E204Q	HDQ-P1	breast	COSMIC	IAVFKE	LIG_APCC_ABBA_1	193:198	Mutation rewiring degron network	0.1667

Kaplan plot for RAD17 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAD17

UniProt ID: O75943

Entrez ID: 5884

Protein name: Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAD17 in