DegronMD

Uniprot ID: O75943

Source protein: Cell cycle checkpoint protein RAD17

Source gene: RAD17

Class: DEG_APCC_DBOX_1

Location: 65:73

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9874

ASA_SCORE: 90.7222

COIL: 0.7216

CONS_SCORE: 0.2382

DSS_SCORE: 0.4543

HELIX: 0.2026

FCONS_SCORE: 1.0385

RIG_SCORE: 0.6867

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E73Q	TCGA-AC-A23H	BRCA	TCGA	KRGNLSSLE	DEG_APCC_DBOX_1	0.5633
p.P62S	TCGA-AX-A2HD	UCEC	TCGA	KRGNLSSLE	DEG_APCC_DBOX_1	0.25
p.P62S	ACH-001570	Skin Cancer	CCLE	KRGNLSSLE	DEG_APCC_DBOX_1	0.25
p.S59N	TCGA-CK-4951	COAD	TCGA	KRGNLSSLE	DEG_APCC_DBOX_1	0.1667
p.E79Q	TCGA-CR-6481	HNSC	TCGA	KRGNLSSLE	DEG_APCC_DBOX_1	0.1667
p.N68H	TCGA-EO-A22U	UCEC	TCGA	KRGNLSSLE	DEG_APCC_DBOX_1	0.6312
p.S81L	TCGA-F7-8489	HNSC	TCGA	KRGNLSSLE	DEG_APCC_DBOX_1	0.5556
p.E78K	DO219024	BLCA	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	0.1944
p.E62Q	DO2401	BRCA	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	0.25
p.E76K	DO219623	BRCA	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	0.25
p.E68Q	DO14990	HNSC	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	0.6744
p.S70L	DO14319	HNSC	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	0.6556
p.P79S	DO45346	LUAD	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	0.1667
p.N57H	DO43755	UCEC	ICGC	KRGNLSSLE	DEG_APCC_DBOX_1	0.1111
p.R75Q	SKG-IIIa	cervix	COSMIC	KRGNLSSLE	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75943	Cell cycle checkpoint protein RAD17	DEG_APCC_DBOX_1	65:73	KRGNLSSLE	APC,CDC20,FZR1	0.9874	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons