DegronMD

Uniprot ID: Q96FA7

Source protein: Putative protein ZBED10P

Source gene: ZBED10P

Class: DEG_SCF_FBW7_1

Location: 227:234

E3 ligase: FBXW7

DEGRON score: 0.9813

ASA_SCORE: 73.425

COIL: 0.6976

CONS_SCORE: 0.0163

DSS_SCORE: 0.5155

HELIX: 0.1669

FCONS_SCORE: 0.0418

RIG_SCORE: 0.7841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P231L	TCGA-W3-AA1V	SKCM	TCGA	ICLTPHRS	DEG_SCF_FBW7_1	0.7582
p.P231L	DO51276	SKCM	ICGC	ICLTPHRS	DEG_SCF_FBW7_1	0.7582
p.L235V	DO50406	ESAD	ICGC	ICLTPHRS	DEG_SCF_FBW7_1	0.3056
p.P231R	DO232555	PBCA	ICGC	ICLTPHRS	DEG_SCF_FBW7_1	0.7512
p.E221Q	DO229475	SKCA	ICGC	ICLTPHRS	DEG_SCF_FBW7_1	0.1667
p.A222G	DO229184	THCA	ICGC	ICLTPHRS	DEG_SCF_FBW7_1	0.1944
p.P224T	SIDM00837	Colorectal Carcinoma	GDSC	ICLTPHRS	DEG_SCF_FBW7_1	0.25
p.P224T	ACH-000958	Colon/Colorectal Cancer	CCLE	ICLTPHRS	DEG_SCF_FBW7_1	0.25
p.P224T	SW48	large_intestine	COSMIC	ICLTPHRS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96FA7	Putative protein ZBED10P	DEG_SCF_FBW7_1	227:234	ICLTPHRS	FBXW7	0.9813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons