DegronMD

Uniprot ID: Q96EM0

Source protein: Trans-3-hydroxy-L-proline dehydratase

Source gene: L3HYPDH

Class: LIG_APCC_ABBA_1

Location: 260:265

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.637

ASA_SCORE: 20.95

COIL: 0.2737

CONS_SCORE: 0.598

DSS_SCORE: 0.3728

HELIX: 0.0612

FCONS_SCORE: 0.9666

RIG_SCORE: 0.916

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N259T	TCGA-B0-5121	KIRC	TCGA	ICVFAD	LIG_APCC_ABBA_1	0.3056
p.E255K	TCGA-EE-A181	SKCM	TCGA	ICVFAD	LIG_APCC_ABBA_1	0.1944
p.A251T	TCGA-HF-7132	STAD	TCGA	ICVFAD	LIG_APCC_ABBA_1	0.0833
p.A251D	SIDM01129	Small Cell Lung Carcinoma	GDSC	ICVFAD	LIG_APCC_ABBA_1	0.0833
p.A251D	NCI-H524	lung	COSMIC	ICVFAD	LIG_APCC_ABBA_1	0.0833
p.V268I	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	ICVFAD	LIG_APCC_ABBA_1	0.25
p.V268I	NCI-H1435	lung	COSMIC	ICVFAD	LIG_APCC_ABBA_1	0.25
p.C261F	SIDM00783	Colorectal Carcinoma	GDSC	ICVFAD	LIG_APCC_ABBA_1	0.5996
p.C261F	HCT-116	large_intestine	COSMIC	ICVFAD	LIG_APCC_ABBA_1	0.5996

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EM0	Trans-3-hydroxy-L-proline dehydratase	LIG_APCC_ABBA_1	260:265	ICVFAD	APC,CDC20,FZR1	0.637	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons