DegronMD - Q96EM0(L3HYPDH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G28V	TCGA-73-4658	LUAD	TCGA	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation rewiring degron network	0.1389
p.G28V	DO23663	LUAD	ICGC	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation rewiring degron network	0.1389
p.G28S	TCGA-73-4658	LUAD	TCGA	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation rewiring degron network	0.1389
p.G28S	DO23663	LUAD	ICGC	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation rewiring degron network	0.1389
p.N259T	TCGA-B0-5121	KIRC	TCGA	ICVFAD	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.3056
p.P15S	TCGA-BF-AAP1	SKCM	TCGA	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation altering degron motif	0.6752
p.P15S	DO219464	SKCM	ICGC	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation altering degron motif	0.6752
p.E255K	TCGA-EE-A181	SKCM	TCGA	ICVFAD	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1944
p.A251T	TCGA-HF-7132	STAD	TCGA	ICVFAD	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.0833
p.D24N	TCGA-VQ-A8P2	STAD	TCGA	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation rewiring degron network	0.25
p.D24N	DO51761	STAD	ICGC	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation rewiring degron network	0.25
p.D13G	DO25290	LUAD	ICGC	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation rewiring degron network	0.2778
p.G18S	DO32778	PAAD	ICGC	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation altering degron motif	0.6993
p.Y21F	DO227681	SKCA	ICGC	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation altering degron motif	0.7528
p.M11I	DO48172	UCEC	ICGC	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation rewiring degron network	0.2222
p.A251D	SIDM01129	Small Cell Lung Carcinoma	GDSC	ICVFAD	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.0833
p.A251D	NCI-H524	lung	COSMIC	ICVFAD	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.0833
p.V268I	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	ICVFAD	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.25
p.V268I	NCI-H1435	lung	COSMIC	ICVFAD	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.25
p.C261F	SIDM00783	Colorectal Carcinoma	GDSC	ICVFAD	LIG_APCC_ABBA_1	260:265	Mutation altering degron motif	0.5996
p.C261F	HCT-116	large intestine	COSMIC	ICVFAD	LIG_APCC_ABBA_1	260:265	Mutation altering degron motif	0.5996
p.F20C	ACH-001664	Gastric Cancer	CCLE	PGTPVLS	DEG_SCF_FBW7_1	15:21	Mutation altering degron motif	0.7108

Kaplan plot for L3HYPDH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

L3HYPDH

UniProt ID: Q96EM0

Entrez ID: 112849

Protein name: Trans-3-hydroxy-L-proline dehydratase (EC 4.2.1.77) (Trans-L-3-hydroxyproline dehydratase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for L3HYPDH in