DegronMD

Uniprot ID: Q96EM0

Source protein: Trans-3-hydroxy-L-proline dehydratase

Source gene: L3HYPDH

Class: DEG_SCF_FBW7_1

Location: 15:21

E3 ligase: FBXW7

DEGRON score: 0.7966

ASA_SCORE: 46.4143

COIL: 0.606

CONS_SCORE: 0.3329

DSS_SCORE: 0.5218

HELIX: 0.0146

FCONS_SCORE: 0.6446

RIG_SCORE: 0.6795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G28V	TCGA-73-4658	LUAD	TCGA	PGTPVLS	DEG_SCF_FBW7_1	0.1389
p.G28V	DO23663	LUAD	ICGC	PGTPVLS	DEG_SCF_FBW7_1	0.1389
p.G28S	TCGA-73-4658	LUAD	TCGA	PGTPVLS	DEG_SCF_FBW7_1	0.1389
p.G28S	DO23663	LUAD	ICGC	PGTPVLS	DEG_SCF_FBW7_1	0.1389
p.P15S	TCGA-BF-AAP1	SKCM	TCGA	PGTPVLS	DEG_SCF_FBW7_1	0.6752
p.P15S	DO219464	SKCM	ICGC	PGTPVLS	DEG_SCF_FBW7_1	0.6752
p.D24N	TCGA-VQ-A8P2	STAD	TCGA	PGTPVLS	DEG_SCF_FBW7_1	0.25
p.D24N	DO51761	STAD	ICGC	PGTPVLS	DEG_SCF_FBW7_1	0.25
p.D13G	DO25290	LUAD	ICGC	PGTPVLS	DEG_SCF_FBW7_1	0.2778
p.G18S	DO32778	PAAD	ICGC	PGTPVLS	DEG_SCF_FBW7_1	0.6993
p.Y21F	DO227681	SKCA	ICGC	PGTPVLS	DEG_SCF_FBW7_1	0.7528
p.M11I	DO48172	UCEC	ICGC	PGTPVLS	DEG_SCF_FBW7_1	0.2222
p.F20C	ACH-001664	Gastric Cancer	CCLE	PGTPVLS	DEG_SCF_FBW7_1	0.7108

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96EM0	Trans-3-hydroxy-L-proline dehydratase	DEG_SCF_FBW7_1	15:21	PGTPVLS	FBXW7	0.7966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons