DegronMD

Uniprot ID: Q16538

Source protein: Probable G-protein coupled receptor 162

Source gene: GPR162

Class: DEG_SCF_FBW7_1

Location: 509:516

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 73.75

COIL: 0.8946

CONS_SCORE: 0.6926

DSS_SCORE: 0.7061

HELIX: 0.0326

FCONS_SCORE: 1.2541

RIG_SCORE: 0.6856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T506I	TCGA-AX-A06F	UCEC	TCGA	IDETPLPS	DEG_SCF_FBW7_1	0.6944
p.R502Q	TCGA-FD-A43X	BLCA	TCGA	IDETPLPS	DEG_SCF_FBW7_1	0.1389
p.T506N	SIDM00315	Glioblastoma	GDSC	IDETPLPS	DEG_SCF_FBW7_1	0.6944
p.T506N	YKG-1	central_nervous_system	COSMIC	IDETPLPS	DEG_SCF_FBW7_1	0.6944
p.E504D	SIDM00474	Ovarian Carcinoma	GDSC	IDETPLPS	DEG_SCF_FBW7_1	0.1944
p.E504D	OV-7	ovary	COSMIC	IDETPLPS	DEG_SCF_FBW7_1	0.1944
p.R526C	SIDM01700	Hodgkin's Lymphoma	GDSC	IDETPLPS	DEG_SCF_FBW7_1	0.0556
p.E503D	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	IDETPLPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16538	Probable G-protein coupled receptor 162	DEG_SCF_FBW7_1	509:516	IDETPLPS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons