DegronMD

Uniprot ID: O15013

Source protein: Rho guanine nucleotide exchange factor 10

Source gene: ARHGEF10

Class: DEG_SCF_FBW7_2

Location: 119:126

E3 ligase: FBXW7

DEGRON score: 0.8371

ASA_SCORE: 82.9125

COIL: 0.7206

CONS_SCORE: 0.2435

DSS_SCORE: 0.5092

HELIX: 0.117

FCONS_SCORE: 1.0699

RIG_SCORE: 0.779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E115K	TCGA-24-2289	OV	TCGA	IDITPFQE	DEG_SCF_FBW7_2	0.2222
p.A112T	TCGA-A5-A2K3	UCEC	TCGA	IDITPFQE	DEG_SCF_FBW7_2	0.25
p.G118V	TCGA-E6-A2P9	UCEC	TCGA	IDITPFQE	DEG_SCF_FBW7_2	0.3056
p.P136L	TCGA-EE-A180	SKCM	TCGA	IDITPFQE	DEG_SCF_FBW7_2	0.0556
p.T122A	DO44440	HNSC	ICGC	IDITPFQE	DEG_SCF_FBW7_2	0.7139
p.M111V	DO41823	UCEC	ICGC	IDITPFQE	DEG_SCF_FBW7_2	0.1111
p.A136T	DO43899	UCEC	ICGC	IDITPFQE	DEG_SCF_FBW7_2	0.0556
p.P110L	DO42793	UCEC	ICGC	IDITPFQE	DEG_SCF_FBW7_2	0.0833
p.P110L	ACH-000684	Kidney Cancer	CCLE	IDITPFQE	DEG_SCF_FBW7_2	0.0833
p.P110L	ACH-002019	Cervical Cancer	CCLE	IDITPFQE	DEG_SCF_FBW7_2	0.0833
p.P110L	KMRC-1	kidney	COSMIC	IDITPFQE	DEG_SCF_FBW7_2	0.0833
p.A136D	SIDM01293	Colorectal Carcinoma	GDSC	IDITPFQE	DEG_SCF_FBW7_2	0.0556
p.Q124E	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	IDITPFQE	DEG_SCF_FBW7_2	0.6744
p.G118C	TGW	autonomic_ganglia	COSMIC	IDITPFQE	DEG_SCF_FBW7_2	0.3056
p.G118C	SNU-C5	large_intestine	COSMIC	IDITPFQE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15013	Rho guanine nucleotide exchange factor 10	DEG_SCF_FBW7_2	119:126	IDITPFQE	FBXW7	0.8371	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons