DegronMD - O15013(ARHGEF10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A145S	TCGA-17-Z014	LUAD	TCGA	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.0556
p.E115K	TCGA-24-2289	OV	TCGA	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation rewiring degron network	0.2222
p.E115K	TCGA-24-2289	OV	TCGA	ITPFQE	LIG_APCC_ABBA_1	121:126	Mutation rewiring degron network	0.1667
p.A112T	TCGA-A5-A2K3	UCEC	TCGA	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation substituting flanking lysine	0.25
p.A112T	TCGA-A5-A2K3	UCEC	TCGA	ITPFQE	LIG_APCC_ABBA_1	121:126	Mutation substituting flanking lysine	0.1944
p.C131Y	TCGA-A8-A09Z	BRCA	TCGA	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.7087
p.L401P	TCGA-AX-A2HD	UCEC	TCGA	ILTPMPE	DEG_SCF_FBW7_2	407:413	Mutation rewiring degron network	0.1667
p.L141F	TCGA-BF-AAOX	SKCM	TCGA	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1667
p.L141F	TCGA-FW-A3R5	SKCM	TCGA	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1667
p.G132C	TCGA-BR-7851	STAD	TCGA	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.76
p.G132C	TCGA-D3-A2JC	SKCM	TCGA	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.76
p.G118V	TCGA-E6-A2P9	UCEC	TCGA	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation rewiring degron network	0.3056
p.G118V	TCGA-E6-A2P9	UCEC	TCGA	ITPFQE	LIG_APCC_ABBA_1	121:126	Mutation rewiring degron network	0.25
p.Q421H	TCGA-EB-A5UM	SKCM	TCGA	ILTPMPE	DEG_SCF_FBW7_2	407:413	Mutation rewiring degron network	0.1111
p.P136L	TCGA-EE-A180	SKCM	TCGA	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.3056
p.P136L	TCGA-EE-A180	SKCM	TCGA	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation rewiring degron network	0.0556
p.P136L	TCGA-EE-A180	SKCM	TCGA	ITPFQE	LIG_APCC_ABBA_1	121:126	Mutation rewiring degron network	0.0556
p.E420D	TCGA-EE-A3AC	SKCM	TCGA	ILTPMPE	DEG_SCF_FBW7_2	407:413	Mutation rewiring degron network	0.1389
p.E137K	DO1160	BRCA	ICGC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2778
p.P129R	DO50323	ESAD	ICGC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.7512
p.E414K	DO50307	ESAD	ICGC	ILTPMPE	DEG_SCF_FBW7_2	407:413	Mutation rewiring degron network	0.3056
p.T122A	DO44440	HNSC	ICGC	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation altering degron motif	0.7139
p.T122A	DO44440	HNSC	ICGC	ITPFQE	LIG_APCC_ABBA_1	121:126	Mutation altering degron motif	0.6028
p.E414V	DO26614	LUSC	ICGC	ILTPMPE	DEG_SCF_FBW7_2	407:413	Mutation rewiring degron network	0.3056
p.E139K	DO30210	OV	ICGC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.2222
p.E406D	DO37631	SKCM	ICGC	ILTPMPE	DEG_SCF_FBW7_2	407:413	Mutation rewiring degron network	0.3056
p.Q407H	DO47282	SKCM	ICGC	ILTPMPE	DEG_SCF_FBW7_2	407:413	Mutation altering degron motif	0.7582
p.M111V	DO41823	UCEC	ICGC	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation rewiring degron network	0.1111
p.M111V	DO41823	UCEC	ICGC	ITPFQE	LIG_APCC_ABBA_1	121:126	Mutation rewiring degron network	0.0556
p.A136T	DO43899	UCEC	ICGC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.3056
p.A136T	DO43899	UCEC	ICGC	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation rewiring degron network	0.0556
p.A136T	DO43899	UCEC	ICGC	ITPFQE	LIG_APCC_ABBA_1	121:126	Mutation rewiring degron network	0.0556
p.G142V	DO43714	UCEC	ICGC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1389
p.P110L	DO42793	UCEC	ICGC	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation rewiring degron network	0.0833
p.P110L	ACH-000684	Kidney Cancer	CCLE	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation rewiring degron network	0.0833
p.P110L	ACH-002019	Cervical Cancer	CCLE	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation rewiring degron network	0.0833
p.P110L	KMRC-1	kidney	COSMIC	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation rewiring degron network	0.0833
p.A136D	SIDM01293	Colorectal Carcinoma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.3056
p.A136D	SIDM01293	Colorectal Carcinoma	GDSC	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation rewiring degron network	0.0556
p.A136D	SIDM01293	Colorectal Carcinoma	GDSC	ITPFQE	LIG_APCC_ABBA_1	121:126	Mutation rewiring degron network	0.0556
p.H144R	SIDM01951	Colorectal Carcinoma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.0833
p.P134L	SIDM00611	Kidney Carcinoma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.6471
p.P134L	KMRC-1	kidney	COSMIC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.6471
p.G142C	SIDM00498	Colorectal Carcinoma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1389
p.G142C	SIDM00324	Neuroblastoma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1389
p.G142C	SIDM01575	Plasma Cell Myeloma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1389
p.G142C	SIDM01451	Pancreatic Carcinoma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1389
p.G142C	TGW	autonomic ganglia	COSMIC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1389
p.G142C	SNU-C5	large intestine	COSMIC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation rewiring degron network	0.1389
p.Q124E	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation altering degron motif	0.6744
p.Q124E	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	ITPFQE	LIG_APCC_ABBA_1	121:126	Mutation altering degron motif	0.6744
p.G118C	TGW	autonomic ganglia	COSMIC	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation rewiring degron network	0.3056
p.G118C	TGW	autonomic ganglia	COSMIC	ITPFQE	LIG_APCC_ABBA_1	121:126	Mutation rewiring degron network	0.25
p.G118C	SNU-C5	large intestine	COSMIC	IDITPFQE	DEG_SCF_FBW7_2	119:126	Mutation rewiring degron network	0.3056
p.G118C	SNU-C5	large intestine	COSMIC	ITPFQE	LIG_APCC_ABBA_1	121:126	Mutation rewiring degron network	0.25
p.C131S	KOSC-2	upper aerodigestive tract	COSMIC	PPTPVPS	DEG_SCF_FBW7_1	129:135	Mutation altering degron motif	0.7541

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF10

UniProt ID: O15013

Entrez ID: 9639

Protein name: Rho guanine nucleotide exchange factor 10

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGEF10 in