DegronMD

Uniprot ID: O15013

Source protein: Rho guanine nucleotide exchange factor 10

Source gene: ARHGEF10

Class: DEG_SCF_FBW7_2

Location: 407:413

E3 ligase: FBXW7

DEGRON score: 0.8775

ASA_SCORE: 86.3286

COIL: 0.9023

CONS_SCORE: 0.444

DSS_SCORE: 0.441

HELIX: 0.0523

FCONS_SCORE: 1.2135

RIG_SCORE: 0.7628

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L401P	TCGA-AX-A2HD	UCEC	TCGA	ILTPMPE	DEG_SCF_FBW7_2	0.1667
p.Q421H	TCGA-EB-A5UM	SKCM	TCGA	ILTPMPE	DEG_SCF_FBW7_2	0.1111
p.E420D	TCGA-EE-A3AC	SKCM	TCGA	ILTPMPE	DEG_SCF_FBW7_2	0.1389
p.E414K	DO50307	ESAD	ICGC	ILTPMPE	DEG_SCF_FBW7_2	0.3056
p.E414V	DO26614	LUSC	ICGC	ILTPMPE	DEG_SCF_FBW7_2	0.3056
p.E406D	DO37631	SKCM	ICGC	ILTPMPE	DEG_SCF_FBW7_2	0.3056
p.Q407H	DO47282	SKCM	ICGC	ILTPMPE	DEG_SCF_FBW7_2	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15013	Rho guanine nucleotide exchange factor 10	DEG_SCF_FBW7_2	407:413	ILTPMPE	FBXW7	0.8775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons