DegronMD

Uniprot ID: O15013

Source protein: Rho guanine nucleotide exchange factor 10

Source gene: ARHGEF10

Class: LIG_APCC_ABBA_1

Location: 121:126

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7679

ASA_SCORE: 84.5

COIL: 0.785

CONS_SCORE: 0.2358

DSS_SCORE: 0.5168

HELIX: 0.1432

FCONS_SCORE: 1.0082

RIG_SCORE: 0.7629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E115K	TCGA-24-2289	OV	TCGA	ITPFQE	LIG_APCC_ABBA_1	0.1667
p.A112T	TCGA-A5-A2K3	UCEC	TCGA	ITPFQE	LIG_APCC_ABBA_1	0.1944
p.G118V	TCGA-E6-A2P9	UCEC	TCGA	ITPFQE	LIG_APCC_ABBA_1	0.25
p.P136L	TCGA-EE-A180	SKCM	TCGA	ITPFQE	LIG_APCC_ABBA_1	0.0556
p.T122A	DO44440	HNSC	ICGC	ITPFQE	LIG_APCC_ABBA_1	0.6028
p.M111V	DO41823	UCEC	ICGC	ITPFQE	LIG_APCC_ABBA_1	0.0556
p.A136T	DO43899	UCEC	ICGC	ITPFQE	LIG_APCC_ABBA_1	0.0556
p.A136D	SIDM01293	Colorectal Carcinoma	GDSC	ITPFQE	LIG_APCC_ABBA_1	0.0556
p.Q124E	KARPAS-1106P	haematopoietic_and_lymphoid_tissue	COSMIC	ITPFQE	LIG_APCC_ABBA_1	0.6744
p.G118C	TGW	autonomic_ganglia	COSMIC	ITPFQE	LIG_APCC_ABBA_1	0.25
p.G118C	SNU-C5	large_intestine	COSMIC	ITPFQE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15013	Rho guanine nucleotide exchange factor 10	LIG_APCC_ABBA_1	121:126	ITPFQE	APC,CDC20,FZR1	0.7679	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons