DegronMD

Uniprot ID: O15013

Source protein: Rho guanine nucleotide exchange factor 10

Source gene: ARHGEF10

Class: DEG_SCF_FBW7_1

Location: 129:135

E3 ligase: FBXW7

DEGRON score: 0.9669

ASA_SCORE: 83.2286

COIL: 0.962

CONS_SCORE: 0.2438

DSS_SCORE: 0.6272

HELIX: 0.0281

FCONS_SCORE: 1.0449

RIG_SCORE: 0.6696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A145S	TCGA-17-Z014	LUAD	TCGA	PPTPVPS	DEG_SCF_FBW7_1	0.0556
p.C131Y	TCGA-A8-A09Z	BRCA	TCGA	PPTPVPS	DEG_SCF_FBW7_1	0.7087
p.L141F	TCGA-BF-AAOX	SKCM	TCGA	PPTPVPS	DEG_SCF_FBW7_1	0.1667
p.L141F	TCGA-FW-A3R5	SKCM	TCGA	PPTPVPS	DEG_SCF_FBW7_1	0.1667
p.G132C	TCGA-BR-7851	STAD	TCGA	PPTPVPS	DEG_SCF_FBW7_1	0.76
p.G132C	TCGA-D3-A2JC	SKCM	TCGA	PPTPVPS	DEG_SCF_FBW7_1	0.76
p.P136L	TCGA-EE-A180	SKCM	TCGA	PPTPVPS	DEG_SCF_FBW7_1	0.3056
p.E137K	DO1160	BRCA	ICGC	PPTPVPS	DEG_SCF_FBW7_1	0.2778
p.P129R	DO50323	ESAD	ICGC	PPTPVPS	DEG_SCF_FBW7_1	0.7512
p.E139K	DO30210	OV	ICGC	PPTPVPS	DEG_SCF_FBW7_1	0.2222
p.A136T	DO43899	UCEC	ICGC	PPTPVPS	DEG_SCF_FBW7_1	0.3056
p.G142V	DO43714	UCEC	ICGC	PPTPVPS	DEG_SCF_FBW7_1	0.1389
p.A136D	SIDM01293	Colorectal Carcinoma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	0.3056
p.H144R	SIDM01951	Colorectal Carcinoma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	0.0833
p.P134L	SIDM00611	Kidney Carcinoma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	0.6471
p.P134L	KMRC-1	kidney	COSMIC	PPTPVPS	DEG_SCF_FBW7_1	0.6471
p.G142C	SIDM00498	Colorectal Carcinoma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	0.1389
p.G142C	SIDM00324	Neuroblastoma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	0.1389
p.G142C	SIDM01575	Plasma Cell Myeloma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	0.1389
p.G142C	SIDM01451	Pancreatic Carcinoma	GDSC	PPTPVPS	DEG_SCF_FBW7_1	0.1389
p.G142C	TGW	autonomic_ganglia	COSMIC	PPTPVPS	DEG_SCF_FBW7_1	0.1389
p.G142C	SNU-C5	large_intestine	COSMIC	PPTPVPS	DEG_SCF_FBW7_1	0.1389
p.C131S	KOSC-2	upper_aerodigestive_tract	COSMIC	PPTPVPS	DEG_SCF_FBW7_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15013	Rho guanine nucleotide exchange factor 10	DEG_SCF_FBW7_1	129:135	PPTPVPS	FBXW7	0.9669	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons