DegronMD

Uniprot ID: Q9UI33

Source protein: Sodium channel protein type 11 subunit alpha

Source gene: SCN11A

Class: LIG_APCC_ABBA_1

Location: 966:971

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9648

ASA_SCORE: 82.2667

COIL: 0.6565

CONS_SCORE: 0.324

DSS_SCORE: 0.5719

HELIX: 0.2048

FCONS_SCORE: 1.1568

RIG_SCORE: 0.7313

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P969H	DO48185	UCEC	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.7694
p.W967L	DO37405	SKCM	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.7015
p.E970Q	DO219091	BLCA	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.6744
p.D972V	TCGA-VQ-A8PP	STAD	TCGA	IDMFSE	LIG_APCC_ABBA_1	0.3056
p.D972V	DO51774	STAD	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.3056
p.G964D	DO31574	OV	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.2778
p.P974T	DO234285	ESAD	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.25
p.P974S	DO222753	MELA	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.25
p.H975Y	DO222837	MELA	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.2222
p.L961H	DO50092	COAD	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.1944
p.Q976K	DO229034	LICA	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.1944
p.R960I	TCGA-AP-A056	UCEC	TCGA	IDMFSE	LIG_APCC_ABBA_1	0.1667
p.R960I	TCGA-D3-A2JP	SKCM	TCGA	IDMFSE	LIG_APCC_ABBA_1	0.1667
p.R960I	DO47407	SKCM	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.1667
p.R960I	DO43971	UCEC	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.1667
p.R960K	TCGA-FW-A3R5	SKCM	TCGA	IDMFSE	LIG_APCC_ABBA_1	0.1667
p.R960K	DO37406	SKCM	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.1667
p.D960N	DO47695	SKCM	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.1667
p.I978M	DO220855	MELA	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.1389
p.Q959R	DO229245	THCA	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.1389
p.D980N	DO888	BOCA	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.0833
p.P981L	TCGA-EE-A29T	SKCM	TCGA	IDMFSE	LIG_APCC_ABBA_1	0.0556
p.P981L	DO37742	SKCM	ICGC	IDMFSE	LIG_APCC_ABBA_1	0.0556

Showing 1 to 23 of 23 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UI33	Sodium channel protein type 11 subunit alpha	LIG_APCC_ABBA_1	966:971	IDMFSE	APC,CDC20,FZR1	0.9648	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons