DegronMD - Q9UI33(SCN11A)

FUNCTION: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. {ECO:0000269|PubMed:10580103, ECO:0000269|PubMed:12384689}.

GO - Biological processes (BP): membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]; regulation of ion transmembrane transport [GO:0034765]; regulation of sensory perception of pain [GO:0051930]; response to xenobiotic stimulus [GO:0009410]; sodium ion transmembrane transport [GO:00... View more >>

GO - Molecular function (MF): voltage-gated ion channel activity [GO:0005244]; voltage-gated sodium channel activity [GO:0005248]

GO - Cellular component (CC): axon [GO:0030424]; C-fiber [GO:0044299]; extracellular exosome [GO:0070062]; voltage-gated sodium channel complex [GO:0001518]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.AE920AK	DO222411	MELA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.7778
p.P969H	DO48185	UCEC	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation altering degron motif	0.7694
p.D1791H	TCGA-B6-A0RT	BRCA	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	1785:1791	Mutation altering degron motif	0.7688
p.L919R	TCGA-BR-8589	STAD	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.7316
p.L919R	DO47813	STAD	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.7316
p.A917T	TCGA-EO-A22R	UCEC	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.7139
p.A917T	DO42713	UCEC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.7139
p.W967L	DO37405	SKCM	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation altering degron motif	0.7015
p.L916V	DO50355	ESAD	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.6765
p.E970Q	DO219091	BLCA	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation altering degron motif	0.6744
p.H1789Y	TCGA-FS-A1ZQ	SKCM	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	1785:1791	Mutation altering degron motif	0.6118
p.V926I	DO223524	CLLE	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.5965
p.E923K	TCGA-D3-A1QA	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E923K	TCGA-DA-A3F8	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E923K	TCGA-EE-A2M6	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E923K	DO222514	MELA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E923K	DO37418	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E923K	DO47469	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E923K	DO37976	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E922K	TCGA-EB-A44O	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591

Showing 1 to 20 of 79 entries

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Kaplan plot for SCN11A in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCN11A

UniProt ID: Q9UI33

Entrez ID: 11280

Protein name: Sodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (hNaN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCN11A in