DegronMD - Q9UI33(SCN11A)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1780R	TCGA-05-4410	LUAD	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	1785:1791	Mutation rewiring degron network	0.1944
p.R936H	TCGA-2W-A8YY	CESC	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1111
p.R936H	TCGA-AN-A046	BRCA	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1111
p.R936H	DO1285	BRCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1111
p.R936H	DO223732	CESC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1111
p.T906N	TCGA-50-5933	LUAD	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.0556
p.T906N	DO24800	LUAD	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.0556
p.G1782R	TCGA-50-5941	LUAD	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	1785:1791	Mutation rewiring degron network	0.25
p.R936C	TCGA-A5-A2K3	UCEC	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1111
p.R936C	DO43899	UCEC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1111
p.R960I	TCGA-AP-A056	UCEC	TCGA	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.1667
p.R960I	TCGA-D3-A2JP	SKCM	TCGA	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.1667
p.R960I	DO47407	SKCM	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.1667
p.R960I	DO43971	UCEC	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.1667
p.D1791H	TCGA-B6-A0RT	BRCA	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	1785:1791	Mutation altering degron motif	0.7688
p.L919R	TCGA-BR-8589	STAD	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.7316
p.L919R	DO47813	STAD	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.7316
p.S1779T	TCGA-CC-5259	LIHC	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	1785:1791	Mutation rewiring degron network	0.1667
p.E923K	TCGA-D3-A1QA	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E923K	TCGA-DA-A3F8	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E923K	TCGA-EE-A2M6	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E923K	DO222514	MELA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E923K	DO37418	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E923K	DO47469	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E923K	DO37976	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.A934V	TCGA-D9-A1JW	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1667
p.A934V	DO37786	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1667
p.E922K	TCGA-EB-A44O	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E922K	DO47272	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.D912N	TCGA-EE-A17X	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.2222
p.D912N	DO220894	MELA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.2222
p.D912N	DO37931	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.2222
p.P981L	TCGA-EE-A29T	SKCM	TCGA	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.0556
p.P981L	DO37742	SKCM	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.0556
p.E921K	TCGA-EE-A3AA	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E921K	DO222632	MELA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.E921K	DO37571	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.591
p.D925E	TCGA-EE-A3JE	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.5647
p.D925E	DO48766	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.5647
p.A917T	TCGA-EO-A22R	UCEC	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.7139
p.A917T	DO42713	UCEC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.7139
p.H1789Y	TCGA-FS-A1ZQ	SKCM	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	1785:1791	Mutation altering degron motif	0.6118
p.G1776R	TCGA-FW-A3R5	SKCM	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	1785:1791	Mutation rewiring degron network	0.0833
p.R960K	TCGA-FW-A3R5	SKCM	TCGA	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.1667
p.R960K	DO37406	SKCM	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.1667
p.D932G	TCGA-QC-A7B5	SARC	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.2222
p.D932G	DO220239	SARC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.2222
p.D972V	TCGA-VQ-A8PP	STAD	TCGA	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.3056
p.D972V	DO51774	STAD	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.3056
p.G930C	DO48388	BLCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.2778
p.E970Q	DO219091	BLCA	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation altering degron motif	0.6744
p.D980N	DO888	BOCA	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.0833
p.V926I	DO223524	CLLE	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.5965
p.L961H	DO50092	COAD	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.1944
p.V909I	DO230334	COCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1389
p.V909I	DO227709	COCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1389
p.V909I	DO229480	LAML	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1389
p.V909I	DO229047	LICA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1389
p.V909I	DO230536	LUSC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1389
p.V909I	DO231075	LUSC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1389
p.A920V	DO230347	COCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.5825
p.G908D	DO227639	COCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.1111
p.L916V	DO50355	ESAD	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.6765
p.P974T	DO234285	ESAD	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.25
p.Q976K	DO229034	LICA	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.1944
p.I978M	DO220855	MELA	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.1389
p.AE920AK	DO222411	MELA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation altering degron motif	0.7778
p.P974S	DO222753	MELA	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.25
p.H975Y	DO222837	MELA	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.2222
p.D912V	DO46331	OV	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.2222
p.G964D	DO31574	OV	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.2778
p.D932N	DO229459	SKCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.2222
p.W967L	DO37405	SKCM	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation altering degron motif	0.7015
p.D960N	DO47695	SKCM	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.1667
p.Q959R	DO229245	THCA	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation rewiring degron network	0.1389
p.P969H	DO48185	UCEC	ICGC	IDMFSE	LIG_APCC_ABBA_1	966:971	Mutation altering degron motif	0.7694
p.W915C	SIDM00480	Ovarian Carcinoma	GDSC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.3056
p.W915C	ACH-000704	Ovarian Cancer	CCLE	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.3056
p.W915C	OAW-42	ovary	COSMIC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	916:928	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCN11A

UniProt ID: Q9UI33

Entrez ID: 11280

Protein name: Sodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (hNaN)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCN11A in