DegronMD

Uniprot ID: Q9UI33

Source protein: Sodium channel protein type 11 subunit alpha

Source gene: SCN11A

Class: LIG_APCC_ABBAyCdc20_2

Location: 1785:1791

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6822

ASA_SCORE: 98.2143

COIL: 0.6776

CONS_SCORE: 0.2613

DSS_SCORE: 0.6735

HELIX: 0.0307

FCONS_SCORE: 0.882

RIG_SCORE: 0.7585

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1780R	TCGA-05-4410	LUAD	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G1782R	TCGA-50-5941	LUAD	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	0.25
p.D1791H	TCGA-B6-A0RT	BRCA	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	0.7688
p.S1779T	TCGA-CC-5259	LIHC	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	0.1667
p.H1789Y	TCGA-FS-A1ZQ	SKCM	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	0.6118
p.G1776R	TCGA-FW-A3R5	SKCM	TCGA	KGKVHCD	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UI33	Sodium channel protein type 11 subunit alpha	LIG_APCC_ABBAyCdc20_2	1785:1791	KGKVHCD	APC,CDC20,FZR1	0.6822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons