DegronMD

Uniprot ID: Q9UI33

Source protein: Sodium channel protein type 11 subunit alpha

Source gene: SCN11A

Class: DEG_ODPH_VHL_1

Location: 916:928

E3 ligase: VHL

DEGRON score: 0.9823

ASA_SCORE: 78.9385

COIL: 0.7358

CONS_SCORE: 0.2684

DSS_SCORE: 0.5353

HELIX: 0.1112

FCONS_SCORE: 1.0317

RIG_SCORE: 0.7863

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R936H	TCGA-2W-A8YY	CESC	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1111
p.R936H	TCGA-AN-A046	BRCA	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1111
p.R936H	DO1285	BRCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1111
p.R936H	DO223732	CESC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1111
p.T906N	TCGA-50-5933	LUAD	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.0556
p.T906N	DO24800	LUAD	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.0556
p.R936C	TCGA-A5-A2K3	UCEC	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1111
p.R936C	DO43899	UCEC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1111
p.L919R	TCGA-BR-8589	STAD	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.7316
p.L919R	DO47813	STAD	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.7316
p.E923K	TCGA-D3-A1QA	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.591
p.E923K	TCGA-DA-A3F8	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.591
p.E923K	TCGA-EE-A2M6	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.591
p.E923K	DO222514	MELA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.591
p.E923K	DO37418	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.591
p.E923K	DO47469	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.591
p.E923K	DO37976	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.591
p.A934V	TCGA-D9-A1JW	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1667
p.A934V	DO37786	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1667
p.E922K	TCGA-EB-A44O	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.591
p.E922K	DO47272	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.591
p.D912N	TCGA-EE-A17X	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.2222
p.D912N	DO220894	MELA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.2222
p.D912N	DO37931	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.2222
p.E921K	TCGA-EE-A3AA	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.591
p.E921K	DO222632	MELA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.591
p.E921K	DO37571	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.591
p.D925E	TCGA-EE-A3JE	SKCM	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.5647
p.D925E	DO48766	SKCM	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.5647
p.A917T	TCGA-EO-A22R	UCEC	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.7139
p.A917T	DO42713	UCEC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.7139
p.D932G	TCGA-QC-A7B5	SARC	TCGA	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.2222
p.D932G	DO220239	SARC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.2222
p.G930C	DO48388	BLCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.2778
p.V926I	DO223524	CLLE	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.5965
p.V909I	DO230334	COCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1389
p.V909I	DO227709	COCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1389
p.V909I	DO229480	LAML	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1389
p.V909I	DO229047	LICA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1389
p.V909I	DO230536	LUSC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1389
p.V909I	DO231075	LUSC	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1389
p.A920V	DO230347	COCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.5825
p.G908D	DO227639	COCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.1111
p.L916V	DO50355	ESAD	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.6765
p.AE920AK	DO222411	MELA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.7778
p.D912V	DO46331	OV	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.2222
p.D932N	DO229459	SKCA	ICGC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.2222
p.W915C	SIDM00480	Ovarian Carcinoma	GDSC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.3056
p.W915C	ACH-000704	Ovarian Cancer	CCLE	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.3056
p.W915C	OAW-42	ovary	COSMIC	LAPLAEEEDDVEF	DEG_ODPH_VHL_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPLAEEEDDVEF

Degron related mutations and impact score

Drug responses associated with SCN11A mutations

All proteins holding degron of LAPLAEEEDDVEF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UI33	Sodium channel protein type 11 subunit alpha	DEG_ODPH_VHL_1	916:928	LAPLAEEEDDVEF	VHL	0.9823	More...