DegronMD

Uniprot ID: P47211

Source protein: Galanin receptor type 1

Source gene: GALR1

Class: DEG_SCF_FBW7_1

Location: 338:344

E3 ligase: FBXW7

DEGRON score: 0.8991

ASA_SCORE: 106.5429

COIL: 0.9551

CONS_SCORE: 0.4792

DSS_SCORE: 0.6896

HELIX: 0.0143

FCONS_SCORE: 1.165

RIG_SCORE: 0.6238

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T340I	TCGA-L4-A4E5	LUAD	TCGA	IDTPPST	DEG_SCF_FBW7_1	0.7078
p.T340I	DO24320	LUAD	ICGC	IDTPPST	DEG_SCF_FBW7_1	0.7078
p.S334N	DO229010	COCA	ICGC	IDTPPST	DEG_SCF_FBW7_1	0.2222
p.S334N	DO229013	COCA	ICGC	IDTPPST	DEG_SCF_FBW7_1	0.2222
p.S334N	DO229016	COCA	ICGC	IDTPPST	DEG_SCF_FBW7_1	0.2222
p.S334N	DO229003	COCA	ICGC	IDTPPST	DEG_SCF_FBW7_1	0.2222
p.S334N	DO229005	COCA	ICGC	IDTPPST	DEG_SCF_FBW7_1	0.2222
p.D330N	DO220859	MELA	ICGC	IDTPPST	DEG_SCF_FBW7_1	0.1111
p.V349A	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	IDTPPST	DEG_SCF_FBW7_1	0.1944
p.V349A	NCI-H1155	lung	COSMIC	IDTPPST	DEG_SCF_FBW7_1	0.1944
p.P342L	SIDM00793	Burkitt's Lymphoma	GDSC	IDTPPST	DEG_SCF_FBW7_1	0.6471
p.H348Q	SIDM01689	B-Lymphoblastic Leukemia	GDSC	IDTPPST	DEG_SCF_FBW7_1	0.2222
p.H348Q	ACH-000492	Leukemia	CCLE	IDTPPST	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P47211	Galanin receptor type 1	DEG_SCF_FBW7_1	338:344	IDTPPST	FBXW7	0.8991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons