DegronMD

Uniprot ID: Q5T4T6

Source protein: Synaptonemal complex protein 2-like

Source gene: SYCP2L

Class: LIG_APCC_ABBA_1

Location: 383:388

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5946

ASA_SCORE: 23.1333

COIL: 0.1325

CONS_SCORE: 0.6091

DSS_SCORE: 0.0182

HELIX: 0.0152

FCONS_SCORE: 1.3251

RIG_SCORE: 0.9513

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q390L	TCGA-22-5473	LUSC	TCGA	IEIHFD	LIG_APCC_ABBA_1	0.2778
p.Q390L	DO26467	LUSC	ICGC	IEIHFD	LIG_APCC_ABBA_1	0.2778
p.S394T	TCGA-58-A46M	LUSC	TCGA	IEIHFD	LIG_APCC_ABBA_1	0.1667
p.E379K	TCGA-BS-A0UF	UCEC	TCGA	IEIHFD	LIG_APCC_ABBA_1	0.2222
p.E379K	DO41488	UCEC	ICGC	IEIHFD	LIG_APCC_ABBA_1	0.2222
p.F387S	TCGA-BS-A0UV	UCEC	TCGA	IEIHFD	LIG_APCC_ABBA_1	0.6871
p.F387S	DO42793	UCEC	ICGC	IEIHFD	LIG_APCC_ABBA_1	0.6871
p.S394L	TCGA-BW-A5NO	LIHC	TCGA	IEIHFD	LIG_APCC_ABBA_1	0.1667
p.S394L	TCGA-ZJ-A8QO	CESC	TCGA	IEIHFD	LIG_APCC_ABBA_1	0.1667
p.M373I	TCGA-EB-A3Y7	SKCM	TCGA	IEIHFD	LIG_APCC_ABBA_1	0.0556
p.M373I	TCGA-EB-A5FP	SKCM	TCGA	IEIHFD	LIG_APCC_ABBA_1	0.0556
p.M373I	SIDM00108	Melanoma	GDSC	IEIHFD	LIG_APCC_ABBA_1	0.0556
p.M373I	ACH-000579	Skin Cancer	CCLE	IEIHFD	LIG_APCC_ABBA_1	0.0556
p.M373I	UACC-257	skin	COSMIC	IEIHFD	LIG_APCC_ABBA_1	0.0556
p.S397F	TCGA-EE-A2MM	SKCM	TCGA	IEIHFD	LIG_APCC_ABBA_1	0.0833
p.S397F	TCGA-ER-A194	SKCM	TCGA	IEIHFD	LIG_APCC_ABBA_1	0.0833
p.N392D	TCGA-FI-A2D0	UCEC	TCGA	IEIHFD	LIG_APCC_ABBA_1	0.2222
p.N392D	DO43891	UCEC	ICGC	IEIHFD	LIG_APCC_ABBA_1	0.2222
p.D388Y	TCGA-MX-A666	STAD	TCGA	IEIHFD	LIG_APCC_ABBA_1	0.7325
p.V380G	DO10324	COAD	ICGC	IEIHFD	LIG_APCC_ABBA_1	0.25
p.K378T	SIDM02020	Esophageal Carcinoma	GDSC	IEIHFD	LIG_APCC_ABBA_1	0.3056
p.M381I	SIDM00336	Melanoma	GDSC	IEIHFD	LIG_APCC_ABBA_1	0.2778
p.M381I	ACH-000881	Skin Cancer	CCLE	IEIHFD	LIG_APCC_ABBA_1	0.2778
p.M381I	MEL-JUSO	skin	COSMIC	IEIHFD	LIG_APCC_ABBA_1	0.2778
p.M380I	MEL-JUSO	skin	COSMIC	IEIHFD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T4T6	Synaptonemal complex protein 2-like	LIG_APCC_ABBA_1	383:388	IEIHFD	APC,CDC20,FZR1	0.5946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons