DegronMD - Q5T4T6(SYCP2L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q390L	TCGA-22-5473	LUSC	TCGA	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2778
p.Q390L	TCGA-22-5473	LUSC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.2778
p.Q390L	DO26467	LUSC	ICGC	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2778
p.Q390L	DO26467	LUSC	ICGC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.2778
p.S394T	TCGA-58-A46M	LUSC	TCGA	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1667
p.S394T	TCGA-58-A46M	LUSC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.1667
p.K497N	TCGA-A5-A2K5	UCEC	TCGA	RKHLFSE	LIG_APCC_ABBAyCdc20_2	501:507	Mutation substituting flanking lysine	0.3333
p.F505L	TCGA-AA-3984	COAD	TCGA	RKHLFSE	LIG_APCC_ABBAyCdc20_2	501:507	Mutation altering degron motif	0.6981
p.F505L	DO9002	COAD	ICGC	RKHLFSE	LIG_APCC_ABBAyCdc20_2	501:507	Mutation altering degron motif	0.6981
p.K502T	TCGA-B5-A11E	UCEC	TCGA	RKHLFSE	LIG_APCC_ABBAyCdc20_2	501:507	Mutation altering degron motif	0.6195
p.E379K	TCGA-BS-A0UF	UCEC	TCGA	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2222
p.E379K	TCGA-BS-A0UF	UCEC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.25
p.E379K	DO41488	UCEC	ICGC	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2222
p.E379K	DO41488	UCEC	ICGC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.25
p.F387S	TCGA-BS-A0UV	UCEC	TCGA	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation altering degron motif	0.6871
p.F387S	TCGA-BS-A0UV	UCEC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation altering degron motif	0.6871
p.F387S	DO42793	UCEC	ICGC	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation altering degron motif	0.6871
p.F387S	DO42793	UCEC	ICGC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation altering degron motif	0.6871
p.S394L	TCGA-BW-A5NO	LIHC	TCGA	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1667
p.S394L	TCGA-BW-A5NO	LIHC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.1667
p.S394L	TCGA-ZJ-A8QO	CESC	TCGA	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.1667
p.S394L	TCGA-ZJ-A8QO	CESC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.1667
p.P496L	TCGA-DU-6407	LGG	TCGA	RKHLFSE	LIG_APCC_ABBAyCdc20_2	501:507	Mutation rewiring degron network	0.1944
p.P496L	DO22295	LGG	ICGC	RKHLFSE	LIG_APCC_ABBAyCdc20_2	501:507	Mutation rewiring degron network	0.1944
p.M373I	TCGA-EB-A3Y7	SKCM	TCGA	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.0556
p.M373I	TCGA-EB-A3Y7	SKCM	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.0833
p.M373I	TCGA-EB-A5FP	SKCM	TCGA	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.0556
p.M373I	TCGA-EB-A5FP	SKCM	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.0833
p.M373I	SIDM00108	Melanoma	GDSC	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.0556
p.M373I	SIDM00108	Melanoma	GDSC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.0833
p.M373I	ACH-000579	Skin Cancer	CCLE	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.0556
p.M373I	ACH-000579	Skin Cancer	CCLE	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.0833
p.M373I	UACC-257	skin	COSMIC	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.0556
p.M373I	UACC-257	skin	COSMIC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.0833
p.S397F	TCGA-EE-A2MM	SKCM	TCGA	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.0833
p.S397F	TCGA-EE-A2MM	SKCM	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.0833
p.S397F	TCGA-ER-A194	SKCM	TCGA	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.0833
p.S397F	TCGA-ER-A194	SKCM	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.0833
p.R540I	TCGA-EO-A3B0	UCEC	TCGA	TRSNLRILP	DEG_APCC_DBOX_1	539:547	Mutation altering degron motif	0.8102
p.R540I	DO219773	UCEC	ICGC	TRSNLRILP	DEG_APCC_DBOX_1	539:547	Mutation altering degron motif	0.8102
p.N392D	TCGA-FI-A2D0	UCEC	TCGA	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2222
p.N392D	TCGA-FI-A2D0	UCEC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.2222
p.N392D	DO43891	UCEC	ICGC	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2222
p.N392D	DO43891	UCEC	ICGC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.2222
p.S553G	TCGA-HE-A5NI	KIRP	TCGA	TRSNLRILP	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1667
p.S553G	DO49767	KIRP	ICGC	TRSNLRILP	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1667
p.D388Y	TCGA-MX-A666	STAD	TCGA	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation altering degron motif	0.7325
p.D388Y	TCGA-MX-A666	STAD	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation altering degron motif	0.7325
p.V380G	DO10324	COAD	ICGC	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.25
p.V380G	DO10324	COAD	ICGC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.2778
p.D511Y	DO222884	COCA	ICGC	RKHLFSE	LIG_APCC_ABBAyCdc20_2	501:507	Mutation rewiring degron network	0.2222
p.P493L	DO233234	GACA	ICGC	RKHLFSE	LIG_APCC_ABBAyCdc20_2	501:507	Mutation rewiring degron network	0.1111
p.S515I	DO228948	LICA	ICGC	RKHLFSE	LIG_APCC_ABBAyCdc20_2	501:507	Mutation rewiring degron network	0.1111
p.G556V	DO229026	LICA	ICGC	TRSNLRILP	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.0833
p.G554V	DO229032	LICA	ICGC	TRSNLRILP	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1389
p.G554V	DO229037	LICA	ICGC	TRSNLRILP	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.1389
p.P550S	DO222662	MELA	ICGC	TRSNLRILP	DEG_APCC_DBOX_1	539:547	Mutation rewiring degron network	0.25
p.K378T	SIDM02020	Esophageal Carcinoma	GDSC	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation substituting flanking lysine	0.3056
p.K378T	SIDM02020	Esophageal Carcinoma	GDSC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation substituting flanking lysine	0.3333
p.M381I	SIDM00336	Melanoma	GDSC	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2778
p.M381I	SIDM00336	Melanoma	GDSC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.3056
p.M381I	ACH-000881	Skin Cancer	CCLE	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2778
p.M381I	ACH-000881	Skin Cancer	CCLE	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.3056
p.M381I	MEL-JUSO	skin	COSMIC	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.2778
p.M381I	MEL-JUSO	skin	COSMIC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.3056
p.M372I	UACC-257	skin	COSMIC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.0556
p.M380I	MEL-JUSO	skin	COSMIC	IEIHFD	LIG_APCC_ABBA_1	383:388	Mutation rewiring degron network	0.25
p.M380I	MEL-JUSO	skin	COSMIC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	382:388	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYCP2L

UniProt ID: Q5T4T6

Entrez ID: 221711

Protein name: Synaptonemal complex protein 2-like (SCP-2-like) (145 kDa nucleolar protein homolog) (hsNO145)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYCP2L in