DegronMD

Uniprot ID: Q5T4T6

Source protein: Synaptonemal complex protein 2-like

Source gene: SYCP2L

Class: DEG_APCC_DBOX_1

Location: 539:547

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5969

ASA_SCORE: 108.5

COIL: 0.8903

CONS_SCORE: 0.5334

DSS_SCORE: 0.603

HELIX: 0.0538

FCONS_SCORE: 0.9301

RIG_SCORE: 0.7186

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R540I	TCGA-EO-A3B0	UCEC	TCGA	TRSNLRILP	DEG_APCC_DBOX_1	0.8102
p.R540I	DO219773	UCEC	ICGC	TRSNLRILP	DEG_APCC_DBOX_1	0.8102
p.S553G	TCGA-HE-A5NI	KIRP	TCGA	TRSNLRILP	DEG_APCC_DBOX_1	0.1667
p.S553G	DO49767	KIRP	ICGC	TRSNLRILP	DEG_APCC_DBOX_1	0.1667
p.G556V	DO229026	LICA	ICGC	TRSNLRILP	DEG_APCC_DBOX_1	0.0833
p.G554V	DO229032	LICA	ICGC	TRSNLRILP	DEG_APCC_DBOX_1	0.1389
p.G554V	DO229037	LICA	ICGC	TRSNLRILP	DEG_APCC_DBOX_1	0.1389
p.P550S	DO222662	MELA	ICGC	TRSNLRILP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T4T6	Synaptonemal complex protein 2-like	DEG_APCC_DBOX_1	539:547	TRSNLRILP	APC,CDC20,FZR1	0.5969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons