DegronMD

Uniprot ID: Q5T4T6

Source protein: Synaptonemal complex protein 2-like

Source gene: SYCP2L

Class: LIG_APCC_ABBAyCdc20_2

Location: 501:507

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9617

ASA_SCORE: 114.1429

COIL: 0.6736

CONS_SCORE: 0.4508

DSS_SCORE: 0.6254

HELIX: 0.2489

FCONS_SCORE: 1.2615

RIG_SCORE: 0.7025

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K497N	TCGA-A5-A2K5	UCEC	TCGA	RKHLFSE	LIG_APCC_ABBAyCdc20_2	0.3333
p.F505L	TCGA-AA-3984	COAD	TCGA	RKHLFSE	LIG_APCC_ABBAyCdc20_2	0.6981
p.F505L	DO9002	COAD	ICGC	RKHLFSE	LIG_APCC_ABBAyCdc20_2	0.6981
p.K502T	TCGA-B5-A11E	UCEC	TCGA	RKHLFSE	LIG_APCC_ABBAyCdc20_2	0.6195
p.P496L	TCGA-DU-6407	LGG	TCGA	RKHLFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P496L	DO22295	LGG	ICGC	RKHLFSE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D511Y	DO222884	COCA	ICGC	RKHLFSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P493L	DO233234	GACA	ICGC	RKHLFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S515I	DO228948	LICA	ICGC	RKHLFSE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T4T6	Synaptonemal complex protein 2-like	LIG_APCC_ABBAyCdc20_2	501:507	RKHLFSE	APC,CDC20,FZR1	0.9617	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons