DegronMD

Uniprot ID: Q5T4T6

Source protein: Synaptonemal complex protein 2-like

Source gene: SYCP2L

Class: LIG_APCC_ABBAyCdc20_2

Location: 382:388

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5946

ASA_SCORE: 29.5429

COIL: 0.1294

CONS_SCORE: 0.5975

DSS_SCORE: 0.0177

HELIX: 0.0149

FCONS_SCORE: 1.3188

RIG_SCORE: 0.9488

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q390L	TCGA-22-5473	LUSC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.Q390L	DO26467	LUSC	ICGC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S394T	TCGA-58-A46M	LUSC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.1667
p.E379K	TCGA-BS-A0UF	UCEC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.25
p.E379K	DO41488	UCEC	ICGC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.25
p.F387S	TCGA-BS-A0UV	UCEC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.6871
p.F387S	DO42793	UCEC	ICGC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.6871
p.S394L	TCGA-BW-A5NO	LIHC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S394L	TCGA-ZJ-A8QO	CESC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.1667
p.M373I	TCGA-EB-A3Y7	SKCM	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.M373I	TCGA-EB-A5FP	SKCM	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.M373I	SIDM00108	Melanoma	GDSC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.M373I	ACH-000579	Skin Cancer	CCLE	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.M373I	UACC-257	skin	COSMIC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.S397F	TCGA-EE-A2MM	SKCM	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.S397F	TCGA-ER-A194	SKCM	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.0833
p.N392D	TCGA-FI-A2D0	UCEC	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.N392D	DO43891	UCEC	ICGC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D388Y	TCGA-MX-A666	STAD	TCGA	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.7325
p.V380G	DO10324	COAD	ICGC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.K378T	SIDM02020	Esophageal Carcinoma	GDSC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.3333
p.M381I	SIDM00336	Melanoma	GDSC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.3056
p.M381I	ACH-000881	Skin Cancer	CCLE	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.3056
p.M381I	MEL-JUSO	skin	COSMIC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.3056
p.M372I	UACC-257	skin	COSMIC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.M380I	MEL-JUSO	skin	COSMIC	KIEIHFD	LIG_APCC_ABBAyCdc20_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KIEIHFD

Degron related mutations and impact score

Drug responses associated with SYCP2L mutations

All proteins holding degron of KIEIHFD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T4T6	Synaptonemal complex protein 2-like	LIG_APCC_ABBAyCdc20_2	382:388	KIEIHFD	APC,CDC20,FZR1	0.5946	More...