DegronMD

Uniprot ID: Q8NFU5

Source protein: Inositol polyphosphate multikinase

Source gene: IPMK

Class: DEG_SCF_FBW7_1

Location: 25:32

E3 ligase: FBXW7

DEGRON score: 0.9681

ASA_SCORE: 91.725

COIL: 0.9558

CONS_SCORE: 0.3513

DSS_SCORE: 0.7809

HELIX: 0.0134

FCONS_SCORE: 0.9788

RIG_SCORE: 0.5975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P35L	TCGA-AJ-A3EK	UCEC	TCGA	IESTPEGT	DEG_SCF_FBW7_1	0.25
p.P35L	DO41584	UCEC	ICGC	IESTPEGT	DEG_SCF_FBW7_1	0.25
p.E18D	TCGA-AJ-A3EL	UCEC	TCGA	IESTPEGT	DEG_SCF_FBW7_1	0.1389
p.E18D	DO41542	UCEC	ICGC	IESTPEGT	DEG_SCF_FBW7_1	0.1389
p.R41H	DO48442	BLCA	ICGC	IESTPEGT	DEG_SCF_FBW7_1	0.0833
p.T28I	DO228803	GACA	ICGC	IESTPEGT	DEG_SCF_FBW7_1	0.8189
p.T32N	DO228948	LICA	ICGC	IESTPEGT	DEG_SCF_FBW7_1	0.7055
p.P23Q	DO229025	LICA	ICGC	IESTPEGT	DEG_SCF_FBW7_1	0.2778
p.P33Q	DO229027	LICA	ICGC	IESTPEGT	DEG_SCF_FBW7_1	0.3056
p.P33Q	DO229035	LICA	ICGC	IESTPEGT	DEG_SCF_FBW7_1	0.3056
p.T28A	SIDM01397	Melanoma	GDSC	IESTPEGT	DEG_SCF_FBW7_1	0.825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFU5	Inositol polyphosphate multikinase	DEG_SCF_FBW7_1	25:32	IESTPEGT	FBXW7	0.9681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons