DegronMD

Uniprot ID: P49790

Source protein: Nuclear pore complex protein Nup153

Source gene: NUP153

Class: DEG_SCF_FBW7_1

Location: 697:703

E3 ligase: FBXW7

DEGRON score: 0.7872

ASA_SCORE: 96.4857

COIL: 0.9146

CONS_SCORE: 0.2914

DSS_SCORE: 0.5513

HELIX: 0.0337

FCONS_SCORE: 0.8736

RIG_SCORE: 0.678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T695S	TCGA-61-1998	OV	TCGA	IETPNKS	DEG_SCF_FBW7_1	0.2778
p.T695S	DO28813	OV	ICGC	IETPNKS	DEG_SCF_FBW7_1	0.2778
p.T713P	TCGA-A5-A0G2	UCEC	TCGA	IETPNKS	DEG_SCF_FBW7_1	0.0556
p.T713P	DO41235	UCEC	ICGC	IETPNKS	DEG_SCF_FBW7_1	0.0556
p.N701S	TCGA-RP-A695	SKCM	TCGA	IETPNKS	DEG_SCF_FBW7_1	0.5958
p.N701S	DO51270	SKCM	ICGC	IETPNKS	DEG_SCF_FBW7_1	0.5958
p.A711T	SIDM00217	Colorectal Carcinoma	GDSC	IETPNKS	DEG_SCF_FBW7_1	0.5556
p.A711T	SNU-1040	large_intestine	COSMIC	IETPNKS	DEG_SCF_FBW7_1	0.5556
p.K703N	SIDM00118	Colorectal Carcinoma	GDSC	IETPNKS	DEG_SCF_FBW7_1	0.6918
p.K703N	HCC2998	large_intestine	COSMIC	IETPNKS	DEG_SCF_FBW7_1	0.6918
p.S703R	ACH-000507	Gastric Cancer	CCLE	IETPNKS	DEG_SCF_FBW7_1	0.7427
p.G712R	ACH-000931	Skin Cancer	CCLE	IETPNKS	DEG_SCF_FBW7_1	0.0833
p.G712R	ACH-001024	Skin Cancer	CCLE	IETPNKS	DEG_SCF_FBW7_1	0.0833
p.G712R	CHL-1	skin	COSMIC	IETPNKS	DEG_SCF_FBW7_1	0.0833
p.V712M	NCI-SNU-5	stomach	COSMIC	IETPNKS	DEG_SCF_FBW7_1	0.0833
p.C700Y	RPMI-2650	upper_aerodigestive_tract	COSMIC	IETPNKS	DEG_SCF_FBW7_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49790	Nuclear pore complex protein Nup153	DEG_SCF_FBW7_1	697:703	IETPNKS	FBXW7	0.7872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons