DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IEVFSD
Uniprot ID:
Q9Y4K1
Source protein:
Beta/gamma crystallin domain-containing protein 1
Source gene:
CRYBG1
Class:
LIG_APCC_ABBA_1
Location:
1037:1042
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5629
ASA_SCORE:
46.8
COIL:
0.3383
CONS_SCORE:
0.9084
DSS_SCORE:
0.1449
HELIX:
0.0128
FCONS_SCORE:
1.0602
RIG_SCORE:
0.925
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L1051P
SIDM00672
Hepatocellular Carcinoma
GDSC
IEVFSD
LIG_APCC_ABBA_1
0.0833
p.L1051P
Hep_3B2_1-7
NS
COSMIC
IEVFSD
LIG_APCC_ABBA_1
0.0833
Drug responses associated with CRYBG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IEVFSD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y4K1
Beta/gamma crystallin domain-containing protein 1
LIG_APCC_ABBA_1
1037:1042
IEVFSD
APC,CDC20,FZR1
0.5629
More...