DegronMD

Uniprot ID: Q8WW22

Source protein: DnaJ homolog subfamily A member 4

Source gene: DNAJA4

Class: LIG_APCC_ABBA_1

Location: 209:214

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.88

ASA_SCORE: 54.25

COIL: 0.2382

CONS_SCORE: 0.6193

DSS_SCORE: 0.3945

HELIX: 0.0012

FCONS_SCORE: 1.178

RIG_SCORE: 0.833

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E224K	TCGA-A5-A2K7	UCEC	TCGA	IEVHVE	LIG_APCC_ABBA_1	0.0556
p.R216H	TCGA-AP-A056	UCEC	TCGA	IEVHVE	LIG_APCC_ABBA_1	0.2778
p.I203V	TCGA-BR-6706	STAD	TCGA	IEVHVE	LIG_APCC_ABBA_1	0.1667
p.C210F	TCGA-DD-AACV	LIHC	TCGA	IEVHVE	LIG_APCC_ABBA_1	0.7108
p.Q204E	TCGA-XF-AAML	BLCA	TCGA	IEVHVE	LIG_APCC_ABBA_1	0.1944
p.R204C	DO7962	COAD	ICGC	IEVHVE	LIG_APCC_ABBA_1	0.1944
p.R204S	DO47491	SKCM	ICGC	IEVHVE	LIG_APCC_ABBA_1	0.1944
p.M217I	DO38006	SKCM	ICGC	IEVHVE	LIG_APCC_ABBA_1	0.25
p.I208M	DO43186	UCEC	ICGC	IEVHVE	LIG_APCC_ABBA_1	0.3056
p.K222N	DO43907	UCEC	ICGC	IEVHVE	LIG_APCC_ABBA_1	0.2222
p.E209D	ACH-000786	Lymphoma	CCLE	IEVHVE	LIG_APCC_ABBA_1	0.6758
p.E209D	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	IEVHVE	LIG_APCC_ABBA_1	0.6758
p.K207M	MSTO-211H	pleura	COSMIC	IEVHVE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WW22	DnaJ homolog subfamily A member 4	LIG_APCC_ABBA_1	209:214	IEVHVE	APC,CDC20,FZR1	0.88	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons