DegronMD - Q8WW22(DNAJA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P339T	TCGA-15-1446	GBM	TCGA	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation substituting flanking lysine	0.2222
p.V324M	TCGA-23-1114	OV	TCGA	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation rewiring degron network	0.2778
p.S319F	TCGA-5L-AAT1	BRCA	TCGA	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation rewiring degron network	0.1389
p.E224K	TCGA-A5-A2K7	UCEC	TCGA	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.0556
p.G328R	TCGA-AA-3833	COAD	TCGA	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation altering degron motif	0.7568
p.G328R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation altering degron motif	0.7568
p.G328R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation altering degron motif	0.7568
p.G328R	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation altering degron motif	0.7568
p.R216H	TCGA-AP-A056	UCEC	TCGA	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.2778
p.D335N	TCGA-AP-A0LM	UCEC	TCGA	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation rewiring degron network	0.2222
p.I203V	TCGA-BR-6706	STAD	TCGA	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1667
p.C210F	TCGA-DD-AACV	LIHC	TCGA	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation altering degron motif	0.7108
p.G328E	TCGA-DF-A2KU	UCEC	TCGA	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation altering degron motif	0.7199
p.G328V	TCGA-DU-7294	LGG	TCGA	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation altering degron motif	0.7532
p.R334H	TCGA-E6-A1LX	UCEC	TCGA	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation rewiring degron network	0.25
p.V316I	TCGA-EY-A212	UCEC	TCGA	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation rewiring degron network	0.0556
p.Q204E	TCGA-XF-AAML	BLCA	TCGA	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1944
p.L340F	DO227935	BRCA	ICGC	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation rewiring degron network	0.0833
p.R204C	DO7962	COAD	ICGC	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1944
p.Q324H	DO8264	COAD	ICGC	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation rewiring degron network	0.2778
p.R204S	DO47491	SKCM	ICGC	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1944
p.M217I	DO38006	SKCM	ICGC	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.25
p.I208M	DO43186	UCEC	ICGC	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.3056
p.K222N	DO43907	UCEC	ICGC	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation substituting flanking lysine	0.2222
p.L337M	ACH-000608	Ovarian Cancer	CCLE	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation rewiring degron network	0.1667
p.E209D	ACH-000786	Lymphoma	CCLE	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation altering degron motif	0.6758
p.E209D	Daudi	haematopoietic and lymphoid tissue	COSMIC	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation altering degron motif	0.6758
p.R323Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation rewiring degron network	0.25
p.R323Q	ACH-000998	Colon/Colorectal Cancer	CCLE	LVIFPE	LIG_APCC_ABBA_1	326:331	Mutation rewiring degron network	0.25
p.K207M	MSTO-211H	pleura	COSMIC	IEVHVE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.2778

Kaplan plot for DNAJA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAJA4

UniProt ID: Q8WW22

Entrez ID: 55466

Protein name: DnaJ homolog subfamily A member 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAJA4 in