DegronMD

Uniprot ID: Q8WW22

Source protein: DnaJ homolog subfamily A member 4

Source gene: DNAJA4

Class: LIG_APCC_ABBA_1

Location: 326:331

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9159

ASA_SCORE: 47.35

COIL: 0.3775

CONS_SCORE: 0.5624

DSS_SCORE: 0.006

HELIX: 0.0118

FCONS_SCORE: 1.2514

RIG_SCORE: 0.9322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P339T	TCGA-15-1446	GBM	TCGA	LVIFPE	LIG_APCC_ABBA_1	0.2222
p.V324M	TCGA-23-1114	OV	TCGA	LVIFPE	LIG_APCC_ABBA_1	0.2778
p.S319F	TCGA-5L-AAT1	BRCA	TCGA	LVIFPE	LIG_APCC_ABBA_1	0.1389
p.G328R	TCGA-AA-3833	COAD	TCGA	LVIFPE	LIG_APCC_ABBA_1	0.7568
p.G328R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LVIFPE	LIG_APCC_ABBA_1	0.7568
p.G328R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LVIFPE	LIG_APCC_ABBA_1	0.7568
p.G328R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LVIFPE	LIG_APCC_ABBA_1	0.7568
p.D335N	TCGA-AP-A0LM	UCEC	TCGA	LVIFPE	LIG_APCC_ABBA_1	0.2222
p.G328E	TCGA-DF-A2KU	UCEC	TCGA	LVIFPE	LIG_APCC_ABBA_1	0.7199
p.G328V	TCGA-DU-7294	LGG	TCGA	LVIFPE	LIG_APCC_ABBA_1	0.7532
p.R334H	TCGA-E6-A1LX	UCEC	TCGA	LVIFPE	LIG_APCC_ABBA_1	0.25
p.V316I	TCGA-EY-A212	UCEC	TCGA	LVIFPE	LIG_APCC_ABBA_1	0.0556
p.L340F	DO227935	BRCA	ICGC	LVIFPE	LIG_APCC_ABBA_1	0.0833
p.Q324H	DO8264	COAD	ICGC	LVIFPE	LIG_APCC_ABBA_1	0.2778
p.L337M	ACH-000608	Ovarian Cancer	CCLE	LVIFPE	LIG_APCC_ABBA_1	0.1667
p.R323Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	LVIFPE	LIG_APCC_ABBA_1	0.25
p.R323Q	ACH-000998	Colon/Colorectal Cancer	CCLE	LVIFPE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WW22	DnaJ homolog subfamily A member 4	LIG_APCC_ABBA_1	326:331	LVIFPE	APC,CDC20,FZR1	0.9159	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons