DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IEVYQE
Uniprot ID:
P63165
Source protein:
Small ubiquitin-related modifier 1
Source gene:
SUMO1
Class:
LIG_APCC_ABBA_1
Location:
88:93
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5561
ASA_SCORE:
33.95
COIL:
0.1458
CONS_SCORE:
0.6542
DSS_SCORE:
0.5997
HELIX:
0.0147
FCONS_SCORE:
1.0671
RIG_SCORE:
0.8059
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E89Q
TCGA-MP-A4SY
LUAD
TCGA
IEVYQE
LIG_APCC_ABBA_1
0.5633
p.L90R
DO233885
GACA
ICGC
IEVYQE
LIG_APCC_ABBA_1
0.8428
Drug responses associated with SUMO1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IEVYQE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P63165
Small ubiquitin-related modifier 1
LIG_APCC_ABBA_1
88:93
IEVYQE
APC,CDC20,FZR1
0.5561
More...