DegronMD

Uniprot ID: Q9BWN1

Source protein: Proline-rich protein 14

Source gene: PRR14

Class: DEG_SCF_FBW7_1

Location: 263:270

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 80.425

COIL: 0.7178

CONS_SCORE: 0.8867

DSS_SCORE: 0.5706

HELIX: 0.082

FCONS_SCORE: 1.1059

RIG_SCORE: 0.7009

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S255Y	TCGA-25-2398	OV	TCGA	IFLTPNKT	DEG_SCF_FBW7_1	0.1111
p.S255Y	DO31250	OV	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	0.1111
p.P267L	TCGA-73-4668	LUAD	TCGA	IFLTPNKT	DEG_SCF_FBW7_1	0.7582
p.P267L	DO23961	LUAD	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	0.7582
p.P274T	TCGA-CV-7102	HNSC	TCGA	IFLTPNKT	DEG_SCF_FBW7_1	0.2222
p.P274T	DO14194	HNSC	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	0.2222
p.P271Q	TCGA-D3-A2J8	SKCM	TCGA	IFLTPNKT	DEG_SCF_FBW7_1	0.3056
p.P271Q	DO37778	SKCM	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	0.3056
p.T270I	TCGA-ER-A194	SKCM	TCGA	IFLTPNKT	DEG_SCF_FBW7_1	0.7078
p.T270I	DO47646	SKCM	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	0.7078
p.P276L	TCGA-EY-A215	UCEC	TCGA	IFLTPNKT	DEG_SCF_FBW7_1	0.1667
p.P276L	DO42665	UCEC	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	0.1667
p.V253I	DO233888	GACA	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	0.0556
p.P279S	SIDM01189	Glioblastoma	GDSC	IFLTPNKT	DEG_SCF_FBW7_1	0.0833
p.P279S	SIDM00209	Glioblastoma	GDSC	IFLTPNKT	DEG_SCF_FBW7_1	0.0833
p.P279S	D-423MG	central_nervous_system	COSMIC	IFLTPNKT	DEG_SCF_FBW7_1	0.0833
p.P279S	U-87-MG	central_nervous_system	COSMIC	IFLTPNKT	DEG_SCF_FBW7_1	0.0833
p.P279T	SIDM00983	Bladder Carcinoma	GDSC	IFLTPNKT	DEG_SCF_FBW7_1	0.0833
p.P279T	ACH-000896	Bladder Cancer	CCLE	IFLTPNKT	DEG_SCF_FBW7_1	0.0833
p.P279T	647-V	urinary_tract	COSMIC	IFLTPNKT	DEG_SCF_FBW7_1	0.0833
p.P279Q	ACH-001346	Head and Neck Cancer	CCLE	IFLTPNKT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWN1	Proline-rich protein 14	DEG_SCF_FBW7_1	263:270	IFLTPNKT	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons