DegronMD - Q9BWN1(PRR14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S255Y	TCGA-25-2398	OV	TCGA	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.1111
p.S255Y	DO31250	OV	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.1111
p.P267L	TCGA-73-4668	LUAD	TCGA	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation altering degron motif	0.7582
p.P267L	DO23961	LUAD	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation altering degron motif	0.7582
p.P274T	TCGA-CV-7102	HNSC	TCGA	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.2222
p.P274T	DO14194	HNSC	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.2222
p.P271Q	TCGA-D3-A2J8	SKCM	TCGA	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.3056
p.P271Q	DO37778	SKCM	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.3056
p.T270I	TCGA-ER-A194	SKCM	TCGA	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation altering degron motif	0.7078
p.T270I	DO47646	SKCM	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation altering degron motif	0.7078
p.R240S	TCGA-ER-A1A1	SKCM	TCGA	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.1667
p.R240S	DO37413	SKCM	ICGC	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.1667
p.P276L	TCGA-EY-A215	UCEC	TCGA	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.1667
p.P276L	DO42665	UCEC	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.1667
p.R240H	TCGA-FI-A2D0	UCEC	TCGA	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.1667
p.R240H	DO43891	UCEC	ICGC	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.1667
p.R240H	SIDM00469	Pancreatic Carcinoma	GDSC	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.1667
p.R240H	PSN1	pancreas	COSMIC	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.1667
p.R238C	DO227657	COCA	ICGC	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.2222
p.V253I	DO233888	GACA	ICGC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.0556
p.R240C	SIDM00078	Oral Cavity Carcinoma	GDSC	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.1667
p.R240C	ACH-000228	Head and Neck Cancer	CCLE	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.1667
p.R240C	BICR31	upper aerodigestive tract	COSMIC	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.1667
p.P279S	SIDM01189	Glioblastoma	GDSC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.0833
p.P279S	SIDM00209	Glioblastoma	GDSC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.0833
p.P279S	D-423MG	central nervous system	COSMIC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.0833
p.P279S	U-87-MG	central nervous system	COSMIC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.0833
p.P279T	SIDM00983	Bladder Carcinoma	GDSC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.0833
p.P279T	ACH-000896	Bladder Cancer	CCLE	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.0833
p.P279T	647-V	urinary tract	COSMIC	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.0833
p.A224T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.25
p.A224T	ACH-002222	Leukemia	CCLE	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.25
p.A224T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LPSTPPPS	DEG_SCF_FBW7_1	227:234	Mutation rewiring degron network	0.25
p.P279Q	ACH-001346	Head and Neck Cancer	CCLE	IFLTPNKT	DEG_SCF_FBW7_1	263:270	Mutation rewiring degron network	0.0833

Kaplan plot for PRR14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRR14

UniProt ID: Q9BWN1

Entrez ID: 78994

Protein name: Proline-rich protein 14

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRR14 in