DegronMD

Uniprot ID: Q9BWN1

Source protein: Proline-rich protein 14

Source gene: PRR14

Class: DEG_SCF_FBW7_1

Location: 227:234

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 77.2375

COIL: 0.97

CONS_SCORE: 0.721

DSS_SCORE: 0.6189

HELIX: 0.0163

FCONS_SCORE: 0.9035

RIG_SCORE: 0.5887

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R240S	TCGA-ER-A1A1	SKCM	TCGA	LPSTPPPS	DEG_SCF_FBW7_1	0.1667
p.R240S	DO37413	SKCM	ICGC	LPSTPPPS	DEG_SCF_FBW7_1	0.1667
p.R240H	TCGA-FI-A2D0	UCEC	TCGA	LPSTPPPS	DEG_SCF_FBW7_1	0.1667
p.R240H	DO43891	UCEC	ICGC	LPSTPPPS	DEG_SCF_FBW7_1	0.1667
p.R240H	SIDM00469	Pancreatic Carcinoma	GDSC	LPSTPPPS	DEG_SCF_FBW7_1	0.1667
p.R240H	PSN1	pancreas	COSMIC	LPSTPPPS	DEG_SCF_FBW7_1	0.1667
p.R238C	DO227657	COCA	ICGC	LPSTPPPS	DEG_SCF_FBW7_1	0.2222
p.R240C	SIDM00078	Oral Cavity Carcinoma	GDSC	LPSTPPPS	DEG_SCF_FBW7_1	0.1667
p.R240C	ACH-000228	Head and Neck Cancer	CCLE	LPSTPPPS	DEG_SCF_FBW7_1	0.1667
p.R240C	BICR31	upper_aerodigestive_tract	COSMIC	LPSTPPPS	DEG_SCF_FBW7_1	0.1667
p.A224T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LPSTPPPS	DEG_SCF_FBW7_1	0.25
p.A224T	ACH-002222	Leukemia	CCLE	LPSTPPPS	DEG_SCF_FBW7_1	0.25
p.A224T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LPSTPPPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWN1	Proline-rich protein 14	DEG_SCF_FBW7_1	227:234	LPSTPPPS	FBXW7	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons