DegronMD

Uniprot ID: Q8WY36

Source protein: HMG box transcription factor BBX

Source gene: BBX

Class: DEG_SCF_FBW7_1

Location: 806:813

E3 ligase: FBXW7

DEGRON score: 0.9763

ASA_SCORE: 85.95

COIL: 0.8364

CONS_SCORE: 0.3772

DSS_SCORE: 0.5851

HELIX: 0.03

FCONS_SCORE: 0.7575

RIG_SCORE: 0.6779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E817K	TCGA-91-8497	LUAD	TCGA	IFNTPEPT	DEG_SCF_FBW7_1	0.2222
p.S805F	TCGA-A5-A2K5	UCEC	TCGA	IFNTPEPT	DEG_SCF_FBW7_1	0.3056
p.V797A	TCGA-BS-A0UF	UCEC	TCGA	IFNTPEPT	DEG_SCF_FBW7_1	0.0833
p.H798R	TCGA-DI-A1BU	UCEC	TCGA	IFNTPEPT	DEG_SCF_FBW7_1	0.1111
p.K799R	DO50820	LIRI	ICGC	IFNTPEPT	DEG_SCF_FBW7_1	0.25
p.K799N	DO26665	LUSC	ICGC	IFNTPEPT	DEG_SCF_FBW7_1	0.25
p.N821D	ACH-002165	Skin Cancer	CCLE	IFNTPEPT	DEG_SCF_FBW7_1	0.1111
p.N821D	MZ2-MEL	skin	COSMIC	IFNTPEPT	DEG_SCF_FBW7_1	0.1111
p.D801E	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	IFNTPEPT	DEG_SCF_FBW7_1	0.3056
p.D821E	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	IFNTPEPT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WY36	HMG box transcription factor BBX	DEG_SCF_FBW7_1	806:813	IFNTPEPT	FBXW7	0.9763	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons