DegronMD

Uniprot ID: O75874

Source protein: Isocitrate dehydrogenase [NADP] cytoplasmic

Source gene: IDH1

Class: LIG_APCC_ABBA_1

Location: 31:36

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9343

ASA_SCORE: 63.5167

COIL: 0.763

CONS_SCORE: 0.7466

DSS_SCORE: 0.0251

HELIX: 0.092

FCONS_SCORE: 1.0795

RIG_SCORE: 0.9367

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P33S	TCGA-AA-3949	COAD	TCGA	IFPYVE	LIG_APCC_ABBA_1	0.6752
p.P33S	TCGA-BF-A1PX	SKCM	TCGA	IFPYVE	LIG_APCC_ABBA_1	0.6752
p.P33S	TCGA-EE-A3JI	SKCM	TCGA	IFPYVE	LIG_APCC_ABBA_1	0.6752
p.P33S	TCGA-W3-AA1V	SKCM	TCGA	IFPYVE	LIG_APCC_ABBA_1	0.6752
p.P33S	DO7798	COAD	ICGC	IFPYVE	LIG_APCC_ABBA_1	0.6752
p.P33S	DO47268	SKCM	ICGC	IFPYVE	LIG_APCC_ABBA_1	0.6752
p.P33S	DO51276	SKCM	ICGC	IFPYVE	LIG_APCC_ABBA_1	0.6752
p.P33S	DO51236	SKCM	ICGC	IFPYVE	LIG_APCC_ABBA_1	0.6752
p.V35M	TCGA-AD-5900	COAD	TCGA	IFPYVE	LIG_APCC_ABBA_1	0.6097
p.V35M	DO8514	COAD	ICGC	IFPYVE	LIG_APCC_ABBA_1	0.6097
p.D43H	TCGA-K4-A83P	BLCA	TCGA	IFPYVE	LIG_APCC_ABBA_1	0.1389
p.D43H	DO49787	BLCA	ICGC	IFPYVE	LIG_APCC_ABBA_1	0.1389
p.F32V	SIDM00861	Ovarian Carcinoma	GDSC	IFPYVE	LIG_APCC_ABBA_1	0.5957
p.D38N	ACH-000279	Bone Cancer	CCLE	IFPYVE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	LIG_APCC_ABBA_1	31:36	IFPYVE	APC,CDC20,FZR1	0.9343	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons