DegronMD

Uniprot ID: Q9Y334

Source protein: von Willebrand factor A domain-containing protein 7

Source gene: VWA7

Class: LIG_APCC_ABBA_1

Location: 412:417

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5388

ASA_SCORE: 7.65

COIL: 0.1465

CONS_SCORE: 0.9128

DSS_SCORE: 0.2272

HELIX: 0.0045

FCONS_SCORE: 1.2605

RIG_SCORE: 0.851

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S419F	TCGA-63-A5MB	LUSC	TCGA	IFVFTD	LIG_APCC_ABBA_1	0.2778
p.S419F	DO52018	LUSC	ICGC	IFVFTD	LIG_APCC_ABBA_1	0.2778
p.T426N	TCGA-BA-A6DJ	HNSC	TCGA	IFVFTD	LIG_APCC_ABBA_1	0.0833
p.T426N	DO52034	HNSC	ICGC	IFVFTD	LIG_APCC_ABBA_1	0.0833
p.L404P	TCGA-G4-6588	COAD	TCGA	IFVFTD	LIG_APCC_ABBA_1	0.1111
p.L404P	DO10140	COAD	ICGC	IFVFTD	LIG_APCC_ABBA_1	0.1111
p.P407H	TCGA-VQ-A8PX	STAD	TCGA	IFVFTD	LIG_APCC_ABBA_1	0.1944
p.P407H	DO51778	STAD	ICGC	IFVFTD	LIG_APCC_ABBA_1	0.1944
p.D411H	DO228483	BRCA	ICGC	IFVFTD	LIG_APCC_ABBA_1	0.3056
p.T416M	DO233731	GACA	ICGC	IFVFTD	LIG_APCC_ABBA_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y334	von Willebrand factor A domain-containing protein 7	LIG_APCC_ABBA_1	412:417	IFVFTD	APC,CDC20,FZR1	0.5388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons