DegronMD

Uniprot ID: Q6PGQ7

Source protein: Protein aurora borealis

Source gene: BORA

Class: DEG_SCF_FBW7_2

Location: 284:291

E3 ligase: FBXW7

DEGRON score: 0.9935

ASA_SCORE: 77.525

COIL: 0.797

CONS_SCORE: 0.4705

DSS_SCORE: 0.5518

HELIX: 0.1294

FCONS_SCORE: 0.9305

RIG_SCORE: 0.7179

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P288Q	TCGA-09-2044	OV	TCGA	IGETPLSE	DEG_SCF_FBW7_2	0.7035
p.P288Q	DO28923	OV	ICGC	IGETPLSE	DEG_SCF_FBW7_2	0.7035
p.I284T	TCGA-AA-3510	COAD	TCGA	IGETPLSE	DEG_SCF_FBW7_2	0.7078
p.I284T	DO7783	COAD	ICGC	IGETPLSE	DEG_SCF_FBW7_2	0.7078
p.K294T	TCGA-AX-A0J0	UCEC	TCGA	IGETPLSE	DEG_SCF_FBW7_2	0.3611
p.K294T	DO41133	UCEC	ICGC	IGETPLSE	DEG_SCF_FBW7_2	0.3611
p.E286Q	TCGA-CG-4443	STAD	TCGA	IGETPLSE	DEG_SCF_FBW7_2	0.5633
p.E286Q	DO38779	STAD	ICGC	IGETPLSE	DEG_SCF_FBW7_2	0.5633
p.I280T	TCGA-D1-A3DA	UCEC	TCGA	IGETPLSE	DEG_SCF_FBW7_2	0.2222
p.I280T	DO43258	UCEC	ICGC	IGETPLSE	DEG_SCF_FBW7_2	0.2222
p.E296K	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	IGETPLSE	DEG_SCF_FBW7_2	0.6389
p.I281T	GP5d	large_intestine	COSMIC	IGETPLSE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PGQ7	Protein aurora borealis	DEG_SCF_FBW7_2	284:291	IGETPLSE	FBXW7	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons