DegronMD - Q6PGQ7(BORA)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P288Q	TCGA-09-2044	OV	TCGA	IGETPLSE	DEG_SCF_FBW7_2	284:291	Mutation altering degron motif	0.7035
p.P288Q	DO28923	OV	ICGC	IGETPLSE	DEG_SCF_FBW7_2	284:291	Mutation altering degron motif	0.7035
p.D116Y	TCGA-13-0885	OV	TCGA	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.25
p.D116Y	DO30490	OV	ICGC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.25
p.D116V	TCGA-13-0885	OV	TCGA	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.25
p.D116V	DO30490	OV	ICGC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.25
p.D510N	TCGA-4Z-AA87	BLCA	TCGA	DSGYNT	DEG_SCF_TRCP1_1	496:501	Mutation rewiring degron network	0.0833
p.D510N	DO218990	BLCA	ICGC	DSGYNT	DEG_SCF_TRCP1_1	496:501	Mutation rewiring degron network	0.0833
p.I284T	TCGA-AA-3510	COAD	TCGA	IGETPLSE	DEG_SCF_FBW7_2	284:291	Mutation altering degron motif	0.7078
p.I284T	DO7783	COAD	ICGC	IGETPLSE	DEG_SCF_FBW7_2	284:291	Mutation altering degron motif	0.7078
p.K294T	TCGA-AX-A0J0	UCEC	TCGA	IGETPLSE	DEG_SCF_FBW7_2	284:291	Mutation substituting flanking lysine	0.3611
p.K294T	DO41133	UCEC	ICGC	IGETPLSE	DEG_SCF_FBW7_2	284:291	Mutation substituting flanking lysine	0.3611
p.E286Q	TCGA-CG-4443	STAD	TCGA	IGETPLSE	DEG_SCF_FBW7_2	284:291	Mutation altering degron motif	0.5633
p.E286Q	DO38779	STAD	ICGC	IGETPLSE	DEG_SCF_FBW7_2	284:291	Mutation altering degron motif	0.5633
p.I280T	TCGA-D1-A3DA	UCEC	TCGA	IGETPLSE	DEG_SCF_FBW7_2	284:291	Mutation rewiring degron network	0.2222
p.I280T	DO43258	UCEC	ICGC	IGETPLSE	DEG_SCF_FBW7_2	284:291	Mutation rewiring degron network	0.2222
p.E102D	TCGA-D3-A2JB	SKCM	TCGA	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.25
p.E102D	DO47607	SKCM	ICGC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.25
p.G200W	TCGA-D3-A2JC	SKCM	TCGA	RRKLFLD	LIG_APCC_ABBAyCdc20_2	193:199	Mutation rewiring degron network	0.3056
p.G200W	DO229022	LICA	ICGC	RRKLFLD	LIG_APCC_ABBAyCdc20_2	193:199	Mutation rewiring degron network	0.3056
p.G200W	DO47578	SKCM	ICGC	RRKLFLD	LIG_APCC_ABBAyCdc20_2	193:199	Mutation rewiring degron network	0.3056
p.F103L	TCGA-DD-A4NJ	LIHC	TCGA	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.2778
p.F103L	DO44873	LIHC	ICGC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.2778
p.E101K	TCGA-DF-A2KU	UCEC	TCGA	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.2222
p.E101K	DO223286	UCEC	ICGC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.2222
p.H117N	TCGA-EY-A1GI	UCEC	TCGA	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.2222
p.H117N	DO41211	UCEC	ICGC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.2222
p.E148D	TCGA-FD-A3B3	BLCA	TCGA	LTIHSE	LIG_APCC_ABBA_1	143:148	Mutation altering degron motif	0.5647
p.E148D	TCGA-FD-A3B3	BLCA	TCGA	KLTIHSE	LIG_APCC_ABBAyCdc20_2	142:148	Mutation altering degron motif	0.5647
p.E148D	DO749	BLCA	ICGC	LTIHSE	LIG_APCC_ABBA_1	143:148	Mutation altering degron motif	0.5647
p.E148D	DO749	BLCA	ICGC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	142:148	Mutation altering degron motif	0.5647
p.K120N	TCGA-VQ-A91D	STAD	TCGA	TKDVIVPSP	DEG_COP1_1	105:113	Mutation blocking ubiquitination signal	0.5833
p.K120N	DO51783	STAD	ICGC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation blocking ubiquitination signal	0.5833
p.T105I	DO225295	BRCA	ICGC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation altering degron motif	0.7078
p.S189Y	DO233819	GACA	ICGC	RRKLFLD	LIG_APCC_ABBAyCdc20_2	193:199	Mutation blocking phosphorylation signal	0.6667
p.V108F	DO229035	LICA	ICGC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation altering degron motif	0.5957
p.I493T	DO231566	LINC	ICGC	DSGYNT	DEG_SCF_TRCP1_1	496:501	Mutation rewiring degron network	0.25
p.N132Y	DO222875	MELA	ICGC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	142:148	Mutation rewiring degron network	0.0556
p.M495I	DO218894	SKCA	ICGC	DSGYNT	DEG_SCF_TRCP1_1	496:501	Mutation rewiring degron network	0.3056
p.Q154R	SIDM02039	Colorectal Carcinoma	GDSC	LTIHSE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.1667
p.Q154R	SIDM02039	Colorectal Carcinoma	GDSC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	142:148	Mutation rewiring degron network	0.1667
p.T113I	SIDM00984	Other Blood Cancers	GDSC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation altering degron motif	0.7078
p.T113I	BONNA-12	haematopoietic and lymphoid tissue	COSMIC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation altering degron motif	0.7078
p.A115T	SIDM00477	Esophageal Carcinoma	GDSC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.2778
p.A115T	OE33	oesophagus	COSMIC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.2778
p.F120V	SIDM00193	Colorectal Carcinoma	GDSC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation blocking ubiquitination signal	0.5833
p.F120V	SNU-81	large intestine	COSMIC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation blocking ubiquitination signal	0.5833
p.T190A	SIDM01112	Osteosarcoma	GDSC	RRKLFLD	LIG_APCC_ABBAyCdc20_2	193:199	Mutation rewiring degron network	0.25
p.T190A	SJSA-1	bone	COSMIC	RRKLFLD	LIG_APCC_ABBAyCdc20_2	193:199	Mutation rewiring degron network	0.25
p.S102G	SIDM00282	Colorectal Carcinoma	GDSC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.25
p.S102G	CW-2	large intestine	COSMIC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.25
p.Y157C	SIDM00503	Gastric Carcinoma	GDSC	LTIHSE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.0833
p.Y157C	SIDM00503	Gastric Carcinoma	GDSC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	142:148	Mutation rewiring degron network	0.0833
p.Y157C	FU97	stomach	COSMIC	LTIHSE	LIG_APCC_ABBA_1	143:148	Mutation rewiring degron network	0.0833
p.Y157C	FU97	stomach	COSMIC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	142:148	Mutation rewiring degron network	0.0833
p.N142S	SIDM01617	Endometrial Carcinoma	GDSC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	142:148	Mutation altering degron motif	0.7069
p.I135T	SIDM01611	Endometrial Carcinoma	GDSC	LTIHSE	LIG_APCC_ABBA_1	143:148	Mutation blocking phosphorylation signal	0.5556
p.I135T	SIDM01611	Endometrial Carcinoma	GDSC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	142:148	Mutation blocking phosphorylation signal	0.5833
p.T115A	ACH-000748	Bone Cancer	CCLE	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.2778
p.S191P	ACH-000962	Ovarian Cancer	CCLE	RRKLFLD	LIG_APCC_ABBAyCdc20_2	193:199	Mutation blocking phosphorylation signal	0.7222
p.S191P	ACH-001145	Ovarian Cancer	CCLE	RRKLFLD	LIG_APCC_ABBAyCdc20_2	193:199	Mutation blocking phosphorylation signal	0.7222
p.P184H	ACH-000996	Endometrial/Uterine Cancer	CCLE	RRKLFLD	LIG_APCC_ABBAyCdc20_2	193:199	Mutation rewiring degron network	0.0833
p.E296K	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	IGETPLSE	DEG_SCF_FBW7_2	284:291	Mutation blocking phosphorylation signal	0.6389
p.F105V	SNU-81	large intestine	COSMIC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation altering degron motif	0.7068
p.S121P	OC-314	ovary	COSMIC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.1111
p.T98I	BONNA-12	haematopoietic and lymphoid tissue	COSMIC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation substituting flanking lysine	0.25
p.A188V	VMRC-RCW	kidney	COSMIC	RRKLFLD	LIG_APCC_ABBAyCdc20_2	193:199	Mutation blocking phosphorylation signal	0.6389
p.I281T	GP5d	large intestine	COSMIC	IGETPLSE	DEG_SCF_FBW7_2	284:291	Mutation rewiring degron network	0.25
p.A100T	OE33	oesophagus	COSMIC	TKDVIVPSP	DEG_COP1_1	105:113	Mutation rewiring degron network	0.1944
p.Y142C	FU97	stomach	COSMIC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	142:148	Mutation altering degron motif	0.7087

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BORA

UniProt ID: Q6PGQ7

Entrez ID: 79866

Protein name: Protein aurora borealis (HsBora)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BORA in