DegronMD

Uniprot ID: Q6PGQ7

Source protein: Protein aurora borealis

Source gene: BORA

Class: DEG_COP1_1

Location: 105:113

E3 ligase: COP1

DEGRON score: 0.9842

ASA_SCORE: 49.6111

COIL: 0.6864

CONS_SCORE: 0.7981

DSS_SCORE: 0.3793

HELIX: 0.0993

FCONS_SCORE: 1.2643

RIG_SCORE: 0.8012

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D116Y	TCGA-13-0885	OV	TCGA	TKDVIVPSP	DEG_COP1_1	0.25
p.D116Y	DO30490	OV	ICGC	TKDVIVPSP	DEG_COP1_1	0.25
p.D116V	TCGA-13-0885	OV	TCGA	TKDVIVPSP	DEG_COP1_1	0.25
p.D116V	DO30490	OV	ICGC	TKDVIVPSP	DEG_COP1_1	0.25
p.E102D	TCGA-D3-A2JB	SKCM	TCGA	TKDVIVPSP	DEG_COP1_1	0.25
p.E102D	DO47607	SKCM	ICGC	TKDVIVPSP	DEG_COP1_1	0.25
p.F103L	TCGA-DD-A4NJ	LIHC	TCGA	TKDVIVPSP	DEG_COP1_1	0.2778
p.F103L	DO44873	LIHC	ICGC	TKDVIVPSP	DEG_COP1_1	0.2778
p.E101K	TCGA-DF-A2KU	UCEC	TCGA	TKDVIVPSP	DEG_COP1_1	0.2222
p.E101K	DO223286	UCEC	ICGC	TKDVIVPSP	DEG_COP1_1	0.2222
p.H117N	TCGA-EY-A1GI	UCEC	TCGA	TKDVIVPSP	DEG_COP1_1	0.2222
p.H117N	DO41211	UCEC	ICGC	TKDVIVPSP	DEG_COP1_1	0.2222
p.K120N	TCGA-VQ-A91D	STAD	TCGA	TKDVIVPSP	DEG_COP1_1	0.5833
p.K120N	DO51783	STAD	ICGC	TKDVIVPSP	DEG_COP1_1	0.5833
p.T105I	DO225295	BRCA	ICGC	TKDVIVPSP	DEG_COP1_1	0.7078
p.V108F	DO229035	LICA	ICGC	TKDVIVPSP	DEG_COP1_1	0.5957
p.T113I	SIDM00984	Other Blood Cancers	GDSC	TKDVIVPSP	DEG_COP1_1	0.7078
p.T113I	BONNA-12	haematopoietic_and_lymphoid_tissue	COSMIC	TKDVIVPSP	DEG_COP1_1	0.7078
p.A115T	SIDM00477	Esophageal Carcinoma	GDSC	TKDVIVPSP	DEG_COP1_1	0.2778
p.A115T	OE33	oesophagus	COSMIC	TKDVIVPSP	DEG_COP1_1	0.2778
p.F120V	SIDM00193	Colorectal Carcinoma	GDSC	TKDVIVPSP	DEG_COP1_1	0.5833
p.F120V	SNU-81	large_intestine	COSMIC	TKDVIVPSP	DEG_COP1_1	0.5833
p.S102G	SIDM00282	Colorectal Carcinoma	GDSC	TKDVIVPSP	DEG_COP1_1	0.25
p.S102G	CW-2	large_intestine	COSMIC	TKDVIVPSP	DEG_COP1_1	0.25
p.T115A	ACH-000748	Bone Cancer	CCLE	TKDVIVPSP	DEG_COP1_1	0.2778
p.F105V	SNU-81	large_intestine	COSMIC	TKDVIVPSP	DEG_COP1_1	0.7068
p.S121P	OC-314	ovary	COSMIC	TKDVIVPSP	DEG_COP1_1	0.1111
p.T98I	BONNA-12	haematopoietic_and_lymphoid_tissue	COSMIC	TKDVIVPSP	DEG_COP1_1	0.25
p.A100T	OE33	oesophagus	COSMIC	TKDVIVPSP	DEG_COP1_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TKDVIVPSP

Degron related mutations and impact score

Drug responses associated with BORA mutations

All proteins holding degron of TKDVIVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PGQ7	Protein aurora borealis	DEG_COP1_1	105:113	TKDVIVPSP	COP1	0.9842	More...