DegronMD

Uniprot ID: Q6PGQ7

Source protein: Protein aurora borealis

Source gene: BORA

Class: LIG_APCC_ABBAyCdc20_2

Location: 193:199

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9672

ASA_SCORE: 82.8429

COIL: 0.4407

CONS_SCORE: 0.85

DSS_SCORE: 0.404

HELIX: 0.3131

FCONS_SCORE: 1.586

RIG_SCORE: 0.7522

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G200W	TCGA-D3-A2JC	SKCM	TCGA	RRKLFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G200W	DO229022	LICA	ICGC	RRKLFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G200W	DO47578	SKCM	ICGC	RRKLFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S189Y	DO233819	GACA	ICGC	RRKLFLD	LIG_APCC_ABBAyCdc20_2	0.6667
p.T190A	SIDM01112	Osteosarcoma	GDSC	RRKLFLD	LIG_APCC_ABBAyCdc20_2	0.25
p.T190A	SJSA-1	bone	COSMIC	RRKLFLD	LIG_APCC_ABBAyCdc20_2	0.25
p.S191P	ACH-000962	Ovarian Cancer	CCLE	RRKLFLD	LIG_APCC_ABBAyCdc20_2	0.7222
p.S191P	ACH-001145	Ovarian Cancer	CCLE	RRKLFLD	LIG_APCC_ABBAyCdc20_2	0.7222
p.P184H	ACH-000996	Endometrial/Uterine Cancer	CCLE	RRKLFLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A188V	VMRC-RCW	kidney	COSMIC	RRKLFLD	LIG_APCC_ABBAyCdc20_2	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PGQ7	Protein aurora borealis	LIG_APCC_ABBAyCdc20_2	193:199	RRKLFLD	APC,CDC20,FZR1	0.9672	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons