DegronMD

Uniprot ID: Q6PGQ7

Source protein: Protein aurora borealis

Source gene: BORA

Class: LIG_APCC_ABBAyCdc20_2

Location: 142:148

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5212

ASA_SCORE: 94.8571

COIL: 0.6923

CONS_SCORE: 0.3508

DSS_SCORE: 0.3862

HELIX: 0.0783

FCONS_SCORE: 0.9152

RIG_SCORE: 0.7501

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E148D	TCGA-FD-A3B3	BLCA	TCGA	KLTIHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E148D	DO749	BLCA	ICGC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.N132Y	DO222875	MELA	ICGC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q154R	SIDM02039	Colorectal Carcinoma	GDSC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.Y157C	SIDM00503	Gastric Carcinoma	GDSC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.Y157C	FU97	stomach	COSMIC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.N142S	SIDM01617	Endometrial Carcinoma	GDSC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	0.7069
p.I135T	SIDM01611	Endometrial Carcinoma	GDSC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	0.5833
p.Y142C	FU97	stomach	COSMIC	KLTIHSE	LIG_APCC_ABBAyCdc20_2	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PGQ7	Protein aurora borealis	LIG_APCC_ABBAyCdc20_2	142:148	KLTIHSE	APC,CDC20,FZR1	0.5212	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons