DegronMD

Uniprot ID: Q6PGQ7

Source protein: Protein aurora borealis

Source gene: BORA

Class: LIG_APCC_ABBA_1

Location: 143:148

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9069

ASA_SCORE: 87.5167

COIL: 0.7032

CONS_SCORE: 0.3519

DSS_SCORE: 0.3739

HELIX: 0.084

FCONS_SCORE: 0.9053

RIG_SCORE: 0.7575

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E148D	TCGA-FD-A3B3	BLCA	TCGA	LTIHSE	LIG_APCC_ABBA_1	0.5647
p.E148D	DO749	BLCA	ICGC	LTIHSE	LIG_APCC_ABBA_1	0.5647
p.Q154R	SIDM02039	Colorectal Carcinoma	GDSC	LTIHSE	LIG_APCC_ABBA_1	0.1667
p.Y157C	SIDM00503	Gastric Carcinoma	GDSC	LTIHSE	LIG_APCC_ABBA_1	0.0833
p.Y157C	FU97	stomach	COSMIC	LTIHSE	LIG_APCC_ABBA_1	0.0833
p.I135T	SIDM01611	Endometrial Carcinoma	GDSC	LTIHSE	LIG_APCC_ABBA_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PGQ7	Protein aurora borealis	LIG_APCC_ABBA_1	143:148	LTIHSE	APC,CDC20,FZR1	0.9069	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons