DegronMD

Uniprot ID: Q6ZU64

Source protein: Cilia- and flagella-associated protein 65

Source gene: CFAP65

Class: DEG_SCF_FBW7_2

Location: 1814:1821

E3 ligase: FBXW7

DEGRON score: 0.9902

ASA_SCORE: 81.05

COIL: 0.9015

CONS_SCORE: 0.3279

DSS_SCORE: 0.6958

HELIX: 0.0461

FCONS_SCORE: 1.2464

RIG_SCORE: 0.6031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1804K	SIDM00331	B-Lymphoblastic Leukemia	GDSC	IGPTPQPE	DEG_SCF_FBW7_2	0.0556
p.Q1829H	SIDM01503	Small Cell Lung Carcinoma	GDSC	IGPTPQPE	DEG_SCF_FBW7_2	0.1111
p.Q1819P	SIDM01608	Endometrial Carcinoma	GDSC	IGPTPQPE	DEG_SCF_FBW7_2	0.5924

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZU64	Cilia- and flagella-associated protein 65	DEG_SCF_FBW7_2	1814:1821	IGPTPQPE	FBXW7	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons