DegronMD

Uniprot ID: Q8TBC3

Source protein: SH3KBP1-binding protein 1

Source gene: SHKBP1

Class: LIG_APCC_ABBA_1

Location: 497:502

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8501

ASA_SCORE: 54.1833

COIL: 0.7582

CONS_SCORE: 0.8234

DSS_SCORE: 0.4954

HELIX: 0.1185

FCONS_SCORE: 1.324

RIG_SCORE: 0.6924

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N495D	TCGA-AP-A1DR	UCEC	TCGA	IGPYGE	LIG_APCC_ABBA_1	0.2778
p.A493T	TCGA-CG-4306	STAD	TCGA	IGPYGE	LIG_APCC_ABBA_1	0.2222
p.P499H	TCGA-EE-A2GH	SKCM	TCGA	IGPYGE	LIG_APCC_ABBA_1	0.7694
p.G490S	TCGA-HT-8018	LGG	TCGA	IGPYGE	LIG_APCC_ABBA_1	0.1389
p.D505N	TCGA-YD-A9TA	SKCM	TCGA	IGPYGE	LIG_APCC_ABBA_1	0.25
p.D505N	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	IGPYGE	LIG_APCC_ABBA_1	0.25
p.D505N	NCI-H520	lung	COSMIC	IGPYGE	LIG_APCC_ABBA_1	0.25
p.R505W	DO4749	BRCA	ICGC	IGPYGE	LIG_APCC_ABBA_1	0.25
p.R505W	DO22237	LGG	ICGC	IGPYGE	LIG_APCC_ABBA_1	0.25
p.R505W	QGP-1	pancreas	COSMIC	IGPYGE	LIG_APCC_ABBA_1	0.25
p.R505W	HSC-39	stomach	COSMIC	IGPYGE	LIG_APCC_ABBA_1	0.25
p.R498H	DO8447	COAD	ICGC	IGPYGE	LIG_APCC_ABBA_1	0.8244
p.R498C	DO233624	GACA	ICGC	IGPYGE	LIG_APCC_ABBA_1	0.8301
p.R498C	SNU-175	large_intestine	COSMIC	IGPYGE	LIG_APCC_ABBA_1	0.8301
p.Q494K	DO20872	KIRP	ICGC	IGPYGE	LIG_APCC_ABBA_1	0.25
p.V509L	DO52311	LIHC	ICGC	IGPYGE	LIG_APCC_ABBA_1	0.1389
p.S492N	SIDM00247	Gastric Carcinoma	GDSC	IGPYGE	LIG_APCC_ABBA_1	0.1944
p.S492N	ACH-000356	Gastric Cancer	CCLE	IGPYGE	LIG_APCC_ABBA_1	0.1944
p.S492N	MKN45	stomach	COSMIC	IGPYGE	LIG_APCC_ABBA_1	0.1944
p.V497M	639-V	urinary_tract	COSMIC	IGPYGE	LIG_APCC_ABBA_1	0.7208
p.C507R	HCT-116	large_intestine	COSMIC	IGPYGE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBC3	SH3KBP1-binding protein 1	LIG_APCC_ABBA_1	497:502	IGPYGE	APC,CDC20,FZR1	0.8501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons